옥시테트라사이클린 (안과용)

항생제 - 테트라사이클린계 (안과용)Highly Important

**옥시테트라사이클린**은 테트라사이클린 계열에 속하는 광범위 정균 항생제입니다. * **수의학적 용도:** 수의 안과에서는 고양이의 클라미디아 및 마이코플라스마 결막염 치료, 그리고 원인 불명의 결막염에 대한 비특이적 또는 대증 요법으로 가장 자주 사용됩니다. * **제형:** 시판되는 안연고는 그람 음성균(예: 녹농균)에 대한 항균 스펙트럼을 넓히기 위해 **폴리믹신 B(Polymyxin B)**와 혼합되어 있습니다.

작용 기전: Oxytetracycline is a bacteriostatic antibiotic that inhibits bacterial protein synthesis. * It reversibly binds to the **30S ribosomal subunit** of susceptible organisms. * This binding blocks the attachment of aminoacyl-tRNA to the mRNA-ribosome complex → **inhibits the addition of amino acids to the growing peptide chain** → halts bacterial growth and replication. * The addition of Polymyxin B (in commercial ointments) disrupts the bacterial cell membrane of gram-negative bacteria, altering permeability and causing cell death.

동물 종별 용량

Cats

Chlamydial/Mycoplasma keratoconjunctivitis · Apply 4 times daily · topical ophthalmic · q6h · 3-4 weeks · Dramatic improvement should be noted in 3-4 days, but treatment should continue for 3-4 weeks for Chlamydia to break the reproductive cycle. Better treatment is oral doxycycline 25 mg PO twice daily for three weeks.
Susceptible infections (when no other agent is suitable) · 10 mg/kg · IM/SC · q24h · Not specified · Only use in cats when no other agent is suitable.

Dogs

Susceptible infections · 10 mg/kg · IM/SC · q24h · Not specified
Susceptible infections · 50 mg/kg loading dose, then 25 mg/kg · PO · q12h · up to 5 days · Give oral dose on an empty stomach.

용량은 면허 수의 전문가를 위한 임상 참고 자료입니다. 항상 최신 라벨과 개별 환자에 대해 확인하십시오.

투여 경로

topical ophthalmicPOIMSCIV

금기

Known hypersensitivity to tetracyclines or polymyxin B
Use of concentrated cattle/sheep depot formulations in small animals
Pregnancy (last 2-3 weeks)
Neonates (first month of life)
Use in cats unless absolutely necessary

이상반응

Local irritation
Hypersensitivity reactions (rare)
Potential for overgrowth of non-susceptible organisms (e.g., fungi) with prolonged use
Vomiting
Diarrhoea
Depression
Hepatotoxicity (rare)
Fever
Hypotension (following IV administration)
Anorexia (especially in cats)
Superinfections (with prolonged use)
Renal tubular functional changes
Teeth staining in developing animals

약물 상호작용

Penicillins · Bactericidal action of penicillins may be inhibited by oxytetracycline · moderate
Antacids (Mg, Ca, Al) · Binds tetracycline, significantly reducing its GI absorption · major
Food or Milk products · Binds tetracycline, reducing its absorption · major
Methoxyflurane · May increase the nephrotoxic effects · major
Theophylline · GI effects of tetracyclines may be increased · moderate

모니터링

Resolution of clinical signs (conjunctival hyperemia, chemosis, ocular discharge)
Signs of local irritation or hypersensitivity
Renal function (BUN, Creatinine, Urinalysis)
Hydration status
Gastrointestinal signs

과용량

Topical overdose is highly unlikely to cause systemic toxicity. If severe local irritation occurs, flush the eye with sterile saline and discontinue use.

VetSheet 약물 레퍼런스는 면허 수의 전문가를 위한 임상 의사결정 보조 도구이며, 전문적 판단이나 제조사의 최신 라벨을 대신하지 않습니다.