์ฅ์ํ ํธ๋ผ์ฌ์ดํด๋ฆฐ (์๊ณผ์ฉ)
**์ฅ์ํ ํธ๋ผ์ฌ์ดํด๋ฆฐ**์ ํ ํธ๋ผ์ฌ์ดํด๋ฆฐ ๊ณ์ด์ ์ํ๋ ๊ด๋ฒ์ ์ ๊ท ํญ์์ ์ ๋๋ค. * **์์ํ์ ์ฉ๋:** ์์ ์๊ณผ์์๋ ๊ณ ์์ด์ ํด๋ผ๋ฏธ๋์ ๋ฐ ๋ง์ด์ฝํ๋ผ์ค๋ง ๊ฒฐ๋ง์ผ ์น๋ฃ, ๊ทธ๋ฆฌ๊ณ ์์ธ ๋ถ๋ช ์ ๊ฒฐ๋ง์ผ์ ๋ํ ๋นํน์ด์ ๋๋ ๋์ฆ ์๋ฒ์ผ๋ก ๊ฐ์ฅ ์์ฃผ ์ฌ์ฉ๋ฉ๋๋ค. * **์ ํ:** ์ํ๋๋ ์์ฐ๊ณ ๋ ๊ทธ๋ ์์ฑ๊ท (์: ๋ น๋๊ท )์ ๋ํ ํญ๊ท ์คํํธ๋ผ์ ๋ํ๊ธฐ ์ํด **ํด๋ฆฌ๋ฏน์ B(Polymyxin B)**์ ํผํฉ๋์ด ์์ต๋๋ค.
์์ฉ ๊ธฐ์ : Oxytetracycline is a bacteriostatic antibiotic that inhibits bacterial protein synthesis. * It reversibly binds to the **30S ribosomal subunit** of susceptible organisms. * This binding blocks the attachment of aminoacyl-tRNA to the mRNA-ribosome complex โ **inhibits the addition of amino acids to the growing peptide chain** โ halts bacterial growth and replication. * The addition of Polymyxin B (in commercial ointments) disrupts the bacterial cell membrane of gram-negative bacteria, altering permeability and causing cell death.
๋๋ฌผ ์ข ๋ณ ์ฉ๋
- Chlamydial/Mycoplasma keratoconjunctivitis ยท Apply 4 times daily ยท topical ophthalmic ยท q6h ยท 3-4 weeks ยท Dramatic improvement should be noted in 3-4 days, but treatment should continue for 3-4 weeks for Chlamydia to break the reproductive cycle. Better treatment is oral doxycycline 25 mg PO twice daily for three weeks.
- Susceptible infections (when no other agent is suitable) ยท 10 mg/kg ยท IM/SC ยท q24h ยท Not specified ยท Only use in cats when no other agent is suitable.
- Susceptible infections ยท 10 mg/kg ยท IM/SC ยท q24h ยท Not specified
- Susceptible infections ยท 50 mg/kg loading dose, then 25 mg/kg ยท PO ยท q12h ยท up to 5 days ยท Give oral dose on an empty stomach.
์ฉ๋์ ๋ฉดํ ์์ ์ ๋ฌธ๊ฐ๋ฅผ ์ํ ์์ ์ฐธ๊ณ ์๋ฃ์ ๋๋ค. ํญ์ ์ต์ ๋ผ๋ฒจ๊ณผ ๊ฐ๋ณ ํ์์ ๋ํด ํ์ธํ์ญ์์ค.
ํฌ์ฌ ๊ฒฝ๋ก
๊ธ๊ธฐ
- Known hypersensitivity to tetracyclines or polymyxin B
- Use of concentrated cattle/sheep depot formulations in small animals
- Pregnancy (last 2-3 weeks)
- Neonates (first month of life)
- Use in cats unless absolutely necessary
์ด์๋ฐ์
- Local irritation
- Hypersensitivity reactions (rare)
- Potential for overgrowth of non-susceptible organisms (e.g., fungi) with prolonged use
- Vomiting
- Diarrhoea
- Depression
- Hepatotoxicity (rare)
- Fever
- Hypotension (following IV administration)
- Anorexia (especially in cats)
- Superinfections (with prolonged use)
- Renal tubular functional changes
- Teeth staining in developing animals
์ฝ๋ฌผ ์ํธ์์ฉ
- Penicillins ยท Bactericidal action of penicillins may be inhibited by oxytetracycline ยท moderate
- Antacids (Mg, Ca, Al) ยท Binds tetracycline, significantly reducing its GI absorption ยท major
- Food or Milk products ยท Binds tetracycline, reducing its absorption ยท major
- Methoxyflurane ยท May increase the nephrotoxic effects ยท major
- Theophylline ยท GI effects of tetracyclines may be increased ยท moderate
๋ชจ๋ํฐ๋ง
- Resolution of clinical signs (conjunctival hyperemia, chemosis, ocular discharge)
- Signs of local irritation or hypersensitivity
- Renal function (BUN, Creatinine, Urinalysis)
- Hydration status
- Gastrointestinal signs
๊ณผ์ฉ๋
Topical overdose is highly unlikely to cause systemic toxicity. If severe local irritation occurs, flush the eye with sterile saline and discontinue use.
VetSheet ์ฝ๋ฌผ ๋ ํผ๋ฐ์ค๋ ๋ฉดํ ์์ ์ ๋ฌธ๊ฐ๋ฅผ ์ํ ์์ ์์ฌ๊ฒฐ์ ๋ณด์กฐ ๋๊ตฌ์ด๋ฉฐ, ์ ๋ฌธ์ ํ๋จ์ด๋ ์ ์กฐ์ฌ์ ์ต์ ๋ผ๋ฒจ์ ๋์ ํ์ง ์์ต๋๋ค.