옥시토신

동물 종별 용량

투여 경로

금기

• Dystocia due to abnormal fetal presentation (unless corrected)
• Closed or unrelaxed cervix
• Known hypersensitivity to oxytocin
• Significant cephalopelvic disproportion
• Obstetrical emergencies where surgical intervention (C-section) is warranted
• Pregnancy (for nasally administered oxytocin)

이상반응

• Uterine cramping and discomfort
• Tetanic uterine contractions (at high doses)
• Uterine rupture
• Fetal compromise or death (due to placental compression)
• Water intoxication (with prolonged high-dose infusions)
• Hypersensitivity reactions (more common with non-synthetic products)

약물 상호작용

• Thiopental · May delay thiopental anesthesia (reported in humans; clinical significance in animals is not firmly established).
• Vasoconstrictors (Sympathomimetics) · Concurrent use post-partum may result in severe hypertension. Monitor closely.

모니터링

• Uterine contractions (frequency, duration, and strength via tokodynamometry if available)
• Status of the cervix (must be dilated)
• Fetal monitoring (heart rate/distress)
• Maternal calcium and glucose levels

과용량

Effects of overdosage on the uterus depend on the stage of the uterus and the position of the fetus(es). * **Uterine Effects:** Hypertonic or tetanic contractions can occur, leading to tumultuous labor, uterine rupture, fetal injury, or fetal death due to compromised placental blood flow. * **Water Intoxication:** Can occur if large doses are infused for a long period, especially with large volumes of electrolyte-free IV fluids. * *Early signs:* Listlessness, depression. * *Severe signs:* Coma, seizures, death. * *Treatment:* Stop oxytocin therapy, restrict water access. Severe cases may require osmotic diuretics (mannitol, urea, dextrose) with or without furosemide.