판크렐리파제

췌장 효소 보충제

판크렐리파제는 주로 돼지 췌장에서 추출한 소화 효소(리파아제, 프로테아제, 아밀라아제)의 복합제입니다. **외분비 췌장 기능 부전(EPI)** 치료의 핵심 약물입니다. EPI는 췌장이 충분한 소화 효소를 합성 및 분비하지 못하여 심각한 소화 불량, 다식증에도 불구하고 체중 감소, 그리고 다량의 지방변을 유발하는 질환입니다. **임상 요점:** * EPI는 췌장 선방 위축으로 인해 저먼 셰퍼드 및 러프 콜리와 같은 특정 품종에서 특히 흔하게 발생합니다. * 진단은 일반적으로 종 특이적 **트립신 유사 면역반응(TLI)** 검사를 통해 확진됩니다. * 매우 효과적이지만, 약 15%의 개는 효소 보충만으로는 최적의 반응을 보이지 않을 수 있으며, 장내 세균 불균형(항생제 반응성 장병증)의 동시 관리, 식이 조절(예: 소화율이 높고 섬유질이 적은 식단) 또는 코발라민(비타민 B12) 보충이 필요할 수 있습니다.

작용 기전: Pancrelipase acts locally in the duodenum and jejunum to replace missing endogenous pancreatic enzymes, facilitating the breakdown of macronutrients into absorbable molecules: * **Lipase** hydrolyzes triglycerides → free fatty acids and monoglycerides. * **Protease** (including trypsin and chymotrypsin) cleaves peptide bonds in proteins → oligopeptides and free amino acids. * **Amylase** hydrolyzes complex carbohydrates (starches) → dextrins and simple sugars (maltose). These enzymes resolve maldigestion and secondary malabsorption, allowing the animal to properly absorb nutrients and gain weight.

동물 종별 용량

Cats

Pancreatic exocrine insufficiency · 0.5-0.75 teaspoonsful with each meal mixed with food · PO · with each meal · Mix with food thoroughly and allow it to stand for 15-20 minutes before feeding. Best results are usually obtained by feeding small meals frequently (at least 3 times per day).
Pancreatic exocrine insufficiency · 1 teaspoonful of powder or finely crushed nonenteric-coated tablets to each of two meals of balanced feline ration · PO · with each meal (twice daily) · Cats that refuse to eat food treated with powder may be dosed with capsules filled with powder or crushed non-enteric coated tablets. Not necessary to incubate before feeding.
Pancreatic exocrine insufficiency · 0.5 teaspoonsful of powder per meal · PO · with each meal
Pancreatic exocrine insufficiency · Initially, one teaspoon per cat per meal · PO · with each meal · When clinical signs have resolved, gradually decrease to the lowest effective dose.

Birds

Pancreatic exocrine insufficiency · 1/8 tsp per kg · PO · with meals · Mix with moistened feed or administer by gavage. Incubate with food for 15 minutes prior to gavage.

SmallMammals

Gastric trichobezoars (Rabbits) · 1 teaspoonful (5 mL) pancrelipase powder plus 3 teaspoonsful (15 mL) of yogurt; let stand for 15 minutes, then give 2-3 mL · PO · q12h · Questionable efficacy for removing 'hairballs', but might help dissolve the protein matrix surrounding hair.

Dogs

투여 경로

금기

Hypersensitivity to pork proteins

이상반응

GI distress (diarrhea, cramping, nausea) at high doses
Oral or esophageal ulcers (from concentrated enzymes)
Oral bleeding (reported in dogs)

약물 상호작용

Antacids (magnesium hydroxide, calcium carbonate) · May diminish the effectiveness of pancrelipase
Cimetidine (or other H2 antagonists) · May increase the amount of pancrelipase that reaches the duodenum

모니터링

Animal's weight
Stool consistency and frequency

과용량

Overdosage may cause diarrhea or other intestinal upset (cramping, nausea). The effects should be temporary; treat by reducing the dosage and providing supportive care if diarrhea is severe.

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