아세트아미노펜 (파라세타몰)

동물 종별 용량

용량은 면허 수의 전문가를 위한 임상 참고 자료입니다. 항상 최신 라벨과 개별 환자에 대해 확인하십시오.

투여 경로

금기

• Cats (absolute contraindication due to fatal toxicosis)
• Patients with pre-existing severe hepatic impairment

이상반응

• Hepatotoxicity (dose-dependent)
• Methaemoglobinaemia (especially in cats)
• Facial edema
• Cyanosis

약물 상호작용

• Metoclopramide · Enhances the absorption of paracetamol, thereby enhancing its clinical and potentially toxic effects. · moderate
• Cytochrome P450 Inducers (e.g., Phenobarbital, certain NSAIDs) · May increase the production of toxic metabolites (NAPQI), enhancing the risk of hepatotoxicity. · major

모니터링

• Liver enzyme panel (ALT, AST, ALP, Bilirubin) if prolonged use or overdose is suspected
• Clinical signs of toxicity (jaundice, vomiting, lethargy)
• Mucous membrane color (monitoring for cyanosis/brown blood indicative of methaemoglobinaemia)

과용량

Overdose of paracetamol causes severe liver damage. Metabolism produces the toxic intermediate **N-acetyl-p-aminobenzoquinonimine (NAPQI)**, which depletes hepatic glutathione, leading to hepatocyte cell death and centrilobular hepatic necrosis. In cats, it causes fatal methaemoglobinaemia. **Treatment:** - Decontamination (emesis/activated charcoal) if ingestion is recent. - **Antidote:** Oral **methionine** or IV **acetylcysteine (N-acetylcysteine)**. These are directed at replenishing hepatic glutathione stores to neutralize NAPQI, though clinical data in veterinary species is limited. - Supportive care (IV fluids, oxygen therapy, blood transfusions if severe methaemoglobinaemia occurs).