파레고릭 (장뇌 아편 틴크)

동물 종별 용량

용량은 면허 수의 전문가를 위한 임상 참고 자료입니다. 항상 최신 라벨과 개별 환자에 대해 확인하십시오.

투여 경로

금기

• Known hypersensitivity to narcotic analgesics
• Patients receiving monoamine oxidase inhibitors (MAOIs)
• Diarrhea caused by toxic ingestion (until the toxin is eliminated from the GI tract)

이상반응

• Dogs: Constipation, bloat, sedation, paralytic ileus, toxic megacolon, pancreatitis, CNS effects
• Cats: Excitatory behavior (controversial use)
• Horses: Delayed clearance of GI microbes, prolonged febrile state

약물 상호작용

• CNS Depressants (anesthetics, antihistamines, phenothiazines, barbiturates, tranquilizers, alcohol) · May cause increased CNS or respiratory depression when used concurrently.
• Monoamine Oxidase Inhibitors (MAOIs, e.g., amitraz, selegiline) · Contraindicated. Opiates should not be used for at least 14 days after receiving MAOIs due to the risk of severe, potentially fatal reactions.

모니터링

• Clinical efficacy (resolution of diarrhea)
• Fluid and electrolyte status (especially in severe diarrhea)
• CNS effects (sedation in dogs, excitation in cats), particularly if using high dosages

과용량

Acute overdosage of opiate antidiarrheals can result in severe **CNS, cardiovascular, gastrointestinal, or respiratory toxicity**. * Because opiates significantly reduce GI motility, absorption of the drug from the GI tract may be delayed and prolonged, leading to a sustained toxic effect. * **Treatment:** Naloxone is the specific reversal agent and may be necessary to reverse opiate-induced respiratory depression and CNS effects. Supportive care is essential.