파로모마이신

동물 종별 용량

용량은 면허 수의 전문가를 위한 임상 참고 자료입니다. 항상 최신 라벨과 개별 환자에 대해 확인하십시오.

투여 경로

금기

• Known hypersensitivity to paromomycin
• Ileus or intestinal obstruction
• Gastrointestinal ulceration
• Presence of blood in the stool (indicates mucosal breakdown and risk of systemic absorption)

이상반응

• Nausea
• Vomiting
• Diarrhea
• Inappetence
• Nonsusceptible bacterial or fungal overgrowth
• Nephrotoxicity (if systemically absorbed)
• Ototoxicity (if systemically absorbed)
• Pancreatitis (if systemically absorbed)
• Blindness (reported in cats)

약물 상호작용

• Digoxin · Paromomycin may reduce digoxin absorption
• Methotrexate · Paromomycin may reduce methotrexate absorption

모니터링

• Clinical efficacy (resolution of diarrhea, negative fecal tests)
• Gastrointestinal adverse effects
• Renal function (especially if used in cats or if GI ulceration is suspected)

과용량

Because paromomycin is not absorbed orally, acute overdose adverse effects should be limited to **gastrointestinal distress** (nausea, vomiting, diarrhea) in patients with an intact GI system. **Chronic overdoses** or administration in patients with compromised GI mucosa may lead to severe systemic toxicity, including nephrotoxicity, ototoxicity, and pancreatitis.