페니실린 V 칼륨

동물 종별 용량

용량은 면허 수의 전문가를 위한 임상 참고 자료입니다. 항상 최신 라벨과 개별 환자에 대해 확인하십시오.

투여 경로

금기

• Known hypersensitivity to penicillins
• Oral administration in patients with septicemia, shock, or grave illness (due to delayed/diminished GI absorption)
• Use in sensitive species (snakes, birds, turtles, guinea pigs, chinchillas) without extreme caution

이상반응

• GI effects (anorexia, vomiting, diarrhea)
• Hypersensitivity reactions (rashes, fever, eosinophilia, anaphylaxis)
• Antibiotic-associated diarrhea and superinfections (due to altered gut flora)
• Neurotoxicity (e.g., ataxia in dogs) at very high doses
• Elevated liver enzymes
• Tachypnea, dyspnea, edema, and tachycardia (reported in dogs)

약물 상호작용

• Aminoglycosides · In vitro synergism against certain bacteria; however, mixing them in the same syringe or fluid line can cause physical inactivation of the aminoglycoside.
• Bacteriostatic Antibiotics (e.g., chloramphenicol, erythromycin, tetracyclines) · May antagonize the bactericidal activity of penicillins, which require actively dividing bacteria to be effective.
• Methotrexate · Penicillins may decrease the renal elimination of methotrexate, potentially increasing its toxicity.
• Probenecid · Competitively blocks the renal tubular secretion of penicillins, significantly increasing their serum levels and half-lives.

모니터링

• Clinical efficacy (resolution of infection signs)
• Adverse GI effects
• Signs of hypersensitivity or allergic reaction

과용량

Acute oral overdoses are unlikely to cause significant problems other than **gastrointestinal distress** (vomiting, diarrhea). In humans, massive overdoses of parenteral penicillins (especially in patients with renal impairment) have induced **CNS effects** and seizures. Treatment is supportive.