ννλ―Έλ
**ννλ―Έλ(Pentamidine)**μ μμνμμ μ£Όλ‘ κ° **리μλ§νΈλͺ¨μΆ©μ¦(Leishmaniosis)**μ 2μ°¨ λλ ꡬμ μΉλ£μ λ‘ μ¬μ©λλ νμμΆ©μ μ λλ€. νΉν 5κ° μν°λͺ¬ μ½λ¬Ό(μ: λ©κΈλ£¨λ―Ό μν°λͺ¨λ€μ΄νΈ λ° μλ μ€ν°λ³΄κΈλ£¨μ½λ€μ΄νΈ)μ λ΄μ±μ΄ μκ²Όμ λ μ¬μ©λ©λλ€. > **κ²½κ³ :** ννλ―Έλμ μΉλ£ μ§μκ° μ’μ λ§Ήλ μ± μ½λ¬Όμ λλ€. νΉν μ μ₯κ³Ό κ°μ μ¬κ°ν λ μ± μμμ μΌμΌν¬ κ°λ₯μ±μ΄ μμΌλ―λ‘ μΉλ£μ μ΄μ κ³Ό μ μ€νκ² λΉκ΅ νκ°ν΄μΌ ν©λλ€. **μμ ν:** μ¬κ°ν λ μ± νλ‘νμΌκ³Ό λ μμ ν λμ(μλ‘νΈλ¦¬λ, λ°ν ν¬μ λ±)μ΄ μκΈ° λλ¬Έμ ννλ―Έλμ 1μ°¨ μ νμ½μΌλ‘ κ±°μ μ¬μ©λμ§ μμ΅λλ€. μΉλ£λ₯Ό μμνκΈ° μ μ νμ μ λ¬Έκ°μ μ‘°μΈμ ꡬν΄μΌ ν©λλ€.
μμ© κΈ°μ : Pentamidine kills protozoans by interacting with **parasite DNA**. It is rapidly taken up by the parasites via a **high-affinity energy-dependent carrier** β disrupts DNA, RNA, and protein synthesis β leads to protozoal death.
λλ¬Ό μ’ λ³ μ©λ
- Leishmaniosis (resistant cases) Β· 4 mg/kg Β· IM Β· q48-72h Β· Seek expert advice on treatment duration Β· Use only when resistance to pentavalent antimony drugs has occurred. Highly toxic.
μ©λμ λ©΄ν μμ μ λ¬Έκ°λ₯Ό μν μμ μ°Έκ³ μλ£μ λλ€. νμ μ΅μ λΌλ²¨κ³Ό κ°λ³ νμμ λν΄ νμΈνμμμ€.
ν¬μ¬ κ²½λ‘
κΈκΈ°
- Impaired liver function
- Impaired kidney function
- Rapid intravenous (IV) injection (due to severe cardiovascular effects)
μ΄μλ°μ
- Pain at the injection site
- Necrosis at the injection site
- Hypotension
- Nausea
- Salivation
- Vomiting
- Diarrhoea
- Hypoglycaemia
- Blood dyscrasias
μ½λ¬Ό μνΈμμ©
- Nephrotoxic drugs (e.g., Aminoglycosides, NSAIDs) Β· Increased risk of severe nephrotoxicity Β· major
λͺ¨λν°λ§
- Renal function (BUN, Creatinine, Urinalysis)
- Liver enzymes (ALT, AST, ALP) and Bilirubin
- Blood glucose concentrations
- Blood pressure (especially around the time of administration)
- Complete Blood Count (CBC) for dyscrasias
- Injection site for signs of necrosis
κ³Όμ©λ
Overdosage significantly increases the risk of severe **hypotension**, **hypoglycaemia**, **acute renal failure**, and **hepatotoxicity**. Treatment is largely supportive and symptomatic, including IV fluid therapy to support blood pressure and renal perfusion, and dextrose supplementation for hypoglycaemia.
VetSheet μ½λ¬Ό λ νΌλ°μ€λ λ©΄ν μμ μ λ¬Έκ°λ₯Ό μν μμ μμ¬κ²°μ 보쑰 λꡬμ΄λ©°, μ λ¬Έμ νλ¨μ΄λ μ μ‘°μ¬μ μ΅μ λΌλ²¨μ λμ νμ§ μμ΅λλ€.