페닐부타존

동물 종별 용량

투여 경로

금기

• Known hypersensitivity to phenylbutazone or other NSAIDs
• History of or preexisting hematologic or bone marrow abnormalities
• Preexisting gastrointestinal ulcers
• Food-producing animals (especially female dairy cattle 20 months of age or older)
• Lactating dairy cattle
• Pre-existing gastrointestinal ulceration
• Renal impairment
• Hepatic impairment
• Hematological disorders
• Use in food-producing animals (banned in many jurisdictions)

이상반응

• Gastrointestinal and oral erosions/ulcers
• Hypoalbuminemia (especially in foals/ponies)
• Renal papillary necrosis and azotemia
• Sodium and water retention (edema)
• Blood dyscrasias (agranulocytosis, aplastic anemia)
• Hepatotoxicity
• Severe tissue necrosis and sloughing (if injected IM or SC)
• CNS stimulation and seizures (if injected intracarotid)
• Gastrointestinal ulceration and bleeding
• Bone marrow suppression (aplastic anemia, leukopenia)
• Renal papillary necrosis
• Sodium and water retention

약물 상호작용

• Furosemide · Phenylbutazone may antagonize the increased renal blood flow effects caused by furosemide.
• Hepatotoxic Drugs · Concurrent administration may increase the chances of hepatotoxicity developing.
• NSAIDs · Concurrent use increases the potential for adverse GI and renal reactions. (Note: 'Stacking' with ketoprofen shows synergistic toxicity).
• Penicillamine · May increase the risk of hematologic and/or renal adverse reactions.
• Penicillin G · Phenylbutazone may increase the plasma half-life of penicillin G.
• Sulfonamides · Phenylbutazone could potentially displace sulfonamides from plasma proteins, increasing the risk for adverse effects.
• Warfarin · Phenylbutazone could potentially displace warfarin from plasma proteins, increasing the risk for bleeding.
• Corticosteroids · Increased risk of gastrointestinal ulceration · major
• Other NSAIDs · Increased risk of gastrointestinal ulceration and renal toxicity · major
• Highly protein-bound drugs (e.g., warfarin) · Displacement from plasma proteins leading to increased free drug concentrations · moderate

모니터링

• Analgesic, anti-inflammatory, and antipyretic efficacy
• Complete blood counts (CBC) with chronic therapy (weekly early in therapy, biweekly later)
• Urinalysis and renal function parameters (serum creatinine/BUN) with chronic therapy
• Plasma protein determinations (especially in ponies, foals, and debilitated animals)
• Complete Blood Count (CBC)
• Renal function (BUN, Creatinine)
• Liver enzymes
• Clinical signs of GI bleeding (melena)

과용량

Manifestations of acute overdosage include prompt respiratory or metabolic acidosis with compensatory hyperventilation, seizures, coma, and acute hypotensive crisis. * **Systemic Effects:** Clinical signs of renal failure (oliguric, proteinuria, hematuria), liver injury (hepatomegaly, jaundice), bone marrow depression, and severe GI ulceration/perforation may develop. * **Dogs:** Common signs include ataxia, seizures, tachycardia, trembling, tremors, vomiting, and tachypnea. Oral LD50 is 332 mg/kg. * **Horses:** Common signs include colic, anorexia, and ataxia. **Treatment:** Standard overdose procedures should be followed (e.g., empty gut following oral ingestion). Institute supportive treatment as necessary. Intravenous diazepam can be used to help control seizures. Monitor fluid therapy carefully, as phenylbutazone may cause fluid retention.