폴리믹신 B

동물 종별 용량

용량은 면허 수의 전문가를 위한 임상 참고 자료입니다. 항상 최신 라벨과 개별 환자에 대해 확인하십시오.

투여 경로

금기

• Ruptured tympanic membrane (tympanum)
• Systemic administration

이상반응

• Nephrotoxicity (if absorbed systemically)
• Ototoxicity (potential, especially if tympanic membrane is ruptured)
• Local irritation

약물 상호작용

• Other antibacterial agents · Acts synergistically by disrupting the outer and cytoplasmic membranes, improving penetration of other agents into bacterial cells. · moderate
• Chlorhexidine · Cationic detergents potentiate the antibacterial effects of polymyxin B against Pseudomonas aeruginosa. · moderate
• EDTA · Chelating agents potentiate the antibacterial effects of polymyxin B against Pseudomonas aeruginosa. · moderate

모니터링

• Resolution of clinical signs (ear, eye, or skin infection)
• Tympanic membrane integrity (must be verified before otic use)

과용량

Systemic absorption (e.g., from ingestion of large amounts or application to extensive deep wounds) can lead to severe **nephrotoxicity** and **neurotoxicity/ototoxicity**. Treatment is supportive.