프라조신

동물 종별 용량

투여 경로

금기

• Preexisting hypotensive conditions
• Pre-existing hypotension
• Hypovolemia
• Known hypersensitivity to alpha-blockers

이상반응

• Hypotension (including orthostatic hypotension/syncope)
• Lethargy
• Dizziness
• Nausea
• Vomiting
• Diarrhea
• Constipation
• Tachyphylaxis (drug tolerance)
• Hypotension (especially first-dose effect)
• Lethargy / Weakness
• Dizziness / Syncope
• Gastrointestinal upset (vomiting, diarrhea)
• Reflex tachycardia

약물 상호작용

• Beta-blocking agents (e.g., propranolol) · May enhance the postural hypotensive effects seen after the first dose of prazosin
• Clonidine · May decrease prazosin antihypertensive effects
• Sildenafil (and other PDE inhibitors) · May increase risk for hypotension
• Verapamil or Nifedipine · May cause synergistic hypotensive effects when used concomitantly with prazosin
• Amlodipine · Additive hypotensive effects · moderate
• ACE Inhibitors (e.g., Benazepril, Enalapril) · Increased risk of severe hypotension · moderate
• Beta-blockers (e.g., Propranolol) · Exacerbation of postural hypotension · moderate
• Sildenafil · Profound hypotension · major

모니터링

• Baseline thoracic radiographs
• Mucous membrane color
• Capillary refill time (CRT)
• Arterial blood pressure
• Venous PO2 (if possible)
• Systemic blood pressure
• Heart rate
• Urine output and ease of urination (if used for urethral spasm)

과용량

Based on ASPCA APCC data (2008-2009): * **Dogs:** Common findings include hyperactivity, tachycardia, hyperthermia, panting, and agitation. * **Cats:** Common findings include tachycardia. **Treatment:** * Evacuate gastric contents and administer activated charcoal using standard precautionary measures if ingestion was recent and cardiovascular status is stable. * Monitor heart rate and blood pressure. * Treat shock using volume expanders and pressor agents if necessary. * Monitor and support renal function.