프리마퀸

동물 종별 용량

용량은 면허 수의 전문가를 위한 임상 참고 자료입니다. 항상 최신 라벨과 개별 환자에 대해 확인하십시오.

투여 경로

금기

• Known hypersensitivity to primaquine
• Concurrent use of bone marrow suppressant medications
• Patients susceptible to granulocytopenia (e.g., lupus, rheumatoid arthritis)
• Glucose-6-Phosphate Dehydrogenase (G-6-PD) deficiency
• Pregnancy
• Lactation

이상반응

• Vomiting (most common in cats)
• Nausea
• Myelosuppression
• Methemoglobinemia
• Hemolysis

약물 상호작용

• Quinacrine · May potentiate the toxicity of one another; use of primaquine within 3 months of quinacrine is not recommended.
• Bone Marrow Depressants (e.g., amphotericin B, azathioprine, chloramphenicol, antineoplastics) · Concurrent use may cause an increased risk for toxicity and severe myelosuppression.
• Hemolytic Drugs (e.g., acetohydroxamic acid, sulfonylureas, quinidine, sulfonamides) · Concurrent use may cause an increased risk for toxicity and hemolysis.

모니터링

• CBC (mandatory, monitor weekly while treating)
• Improved clinical signs (increased appetite and body weight)
• Improvement in anemia

과용량

> **CRITICAL**: In cats, dosages **greater than 1 mg/kg** can be lethal. - **Management**: Overdoses should initially be handled aggressively using standardized protocols for removal of the drug from the gut (emesis, activated charcoal) to prevent absorption. - Provide intensive supportive care for potential methemoglobinemia, hemolysis, and myelosuppression. - Because of the potential seriousness of overdoses, it is strongly recommended to contact an animal poison control center for guidance immediately.