νλ‘리κ²μ€ν€
**νλ‘리κ²μ€ν€**μ μ£Όλ‘ μμΊμ μκ³ μμ΄μ λ°μ μ μ§μ°μν€κ±°λ μ΅μ νκΈ° μν΄ μμνμμ μ¬μ©λλ ν©μ± νλ‘κ²μ€ν κ²μ λλ€. κ³ μμ΄μ μ’μ νΌλΆμΌ μΉλ£μ λ‘λ μΉμΈλμμΌλ, μ΄ μ μμ¦μλ μΌλ°μ μΌλ‘ νΉμ κΈλ£¨μ½μ½λ₯΄ν°μ½μ΄λκ° μ νΈλ©λλ€. > **μμ κ²½κ³ **: νλ‘리κ²μ€ν€μ λμ± μκΆλ΄λ§ μ¦μμ¦(μκΆμΆλμ¦), λΉλ¨λ³ λ° μ μ μ’ μμ λ°μ κ°λ₯μ±μ ν¬ν¨νμ¬ μ₯κΈ°μ μΈ νλ‘κ²μ€ν κ² μ¬μ©μ μ νμ μΈ μνμ μλ°ν©λλ€. μ£Όμν΄μ μ¬μ©ν΄μΌ νλ©° λΉλ¨λ³μ΄ μλ λλ¬Όμκ²λ κΈκΈ°μ λλ€.
μμ© κΈ°μ : Proligestone alters the transcription of DNA β leads to alterations in cellular metabolism β mimics the physiological effects caused by endogenous **progesterone**.
λλ¬Ό μ’ λ³ μ©λ
- Suppression of oestrus Β· 10-33 mg/kg depending on body weight (<5kg: 100-150mg; 5-10kg: 150-250mg; 10-20kg: 250-350mg; 20-30kg: 350-450mg; 30-45kg: 450-550mg; 45-60kg: 550-600mg; >60kg: 10 mg/kg) Β· SC Β· Once Β· Single dose Β· Given once for suppression. Inject into medial side of flank fold.
- Permanent postponement of oestrus Β· 10-33 mg/kg depending on body weight (see weight table) Β· SC Β· 1st dose before pro-oestrus, 2nd dose 3 months later, 3rd dose 4 months later, then every 5 months Β· Ongoing Β· Once dosing ceases, bitches may come into oestrus on average 6-7 months later, but it may take up to 3 years in some cases.
- Acromegaly Β· 10-33 mg/kg depending on body weight (see weight table) Β· SC Β· Monthly Β· Until signs of hair growth are evident
- Postponement of oestrus / Miliary dermatitis Β· Dose not explicitly specified in text; refer to manufacturer guidelines Β· SC Β· Not specified Β· Not specified Β· Authorized for miliary dermatitis, but specific glucocorticoids are preferred.
μ©λμ λ©΄ν μμ μ λ¬Έκ°λ₯Ό μν μμ μ°Έκ³ μλ£μ λλ€. νμ μ΅μ λΌλ²¨κ³Ό κ°λ³ νμμ λν΄ νμΈνμμμ€.
ν¬μ¬ κ²½λ‘
κΈκΈ°
- Diabetic animals (insulin requirements are likely to change unpredictably)
- Bitches before or at their first oestrus
μ΄μλ°μ
- Unpredictable duration of anoestrus (up to 3 years in some bitches)
- Temperament changes (listlessness and depression)
- Polyuria and polydipsia (increased thirst)
- Polyphagia (increased appetite)
- Cystic endometrial hyperplasia / Pyometra
- Diabetes mellitus
- Acromegaly
- Adrenocortical suppression
- Mammary enlargement, lactation, or neoplasia
- Injection site irritation
- Coat colour changes at the injection site
- Calcinosis circumscripta at the injection site
λͺ¨λν°λ§
- Signs of pyometra (vaginal discharge, lethargy, polyuria/polydipsia)
- Blood glucose and clinical signs of diabetes mellitus (excessive thirst and urination)
- Mammary gland changes (enlargement, masses)
- Injection site reactions
κ³Όμ©λ
No specific information provided in the monograph. Overdosage may increase the risk and severity of progestational side effects, including cystic endometrial hyperplasia, diabetes mellitus, and adrenocortical suppression. Treatment is supportive.
VetSheet μ½λ¬Ό λ νΌλ°μ€λ λ©΄ν μμ μ λ¬Έκ°λ₯Ό μν μμ μμ¬κ²°μ 보쑰 λꡬμ΄λ©°, μ λ¬Έμ νλ¨μ΄λ μ μ‘°μ¬μ μ΅μ λΌλ²¨μ λμ νμ§ μμ΅λλ€.