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μλμνλλ¦°μ κ²½κ΅¬μ© **κ΅κ°μ κ²½ ν₯λΆμ± μλ―Ό**μ λλ€. μμνμμλ νλνλ‘νλμλ―Ό(PPA)μ μ¬μ©ν μ μκ±°λ κΈκΈ°μΈ κ²½μ°, λ°λ €κ²¬μ **μλ κ΄μ½κ·Ό κΈ°λ₯ λΆμ (USMI)**μ λν 2μ°¨ μ νμ½μΌλ‘ μ£Όλ‘ μ¬μ©λ©λλ€. λν μ½λ§ν μνμ λ° μνμ± μ¬μ μΉλ£μ λ‘λ μ¬μ©λ©λλ€. > **μμ μμ :** μμ€κΈ μΉλ£μ μμ΄ μλμνλλ¦°μ PPAμ λΉν΄ ν¨λ₯μ΄ λ¨μ΄μ§κ³ λΆμμ©(λΆμ, κ³ νμ λ±)μ μ λ°ν κ°λ₯μ±μ΄ λ λμ κ²μΌλ‘ κ°μ£Όλ©λλ€. λΆλ² λ©μ€μννλ―Ό ν©μ±μ μ κ΅¬μ²΄λ‘ μ¬μ©λκΈ° λλ¬Έμ νλ§€κ° μ격ν μ νλμ΄ μμ΄ μΌλΆ μ§μμμλ ꡬνκΈ° μ΄λ €μΈ μ μμ΅λλ€.
μμ© κΈ°μ : Pseudoephedrine acts as an **indirect-acting sympathomimetic**. * Enters sympathetic nerve terminals β stimulates the release of endogenous **norepinephrine** from storage vesicles. * Norepinephrine binds to **alpha-1 adrenergic receptors** in the smooth muscle of the urethra and blood vessels β **vasoconstriction** and **increased urethral sphincter tone** (preventing urine leakage). * Also weakly stimulates **beta-adrenergic receptors** β positive chronotropic effects (increased heart rate) and mild bronchodilation.
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- As a decongestant Β· 1 mg/kg Β· PO Β· q8h
- For use when an antihistamine/decongestant may be useful using the pyrilamine/pseudoephedrine oral granules Β· Β½ ounce (1 tablespoonful) per 1,000 lb body weight. May mix with feed and repeated at 12 our intervals if needed. Β· PO Β· q12h Β· Do not use at least 72 hours before sporting events. ARCI UCGFS CLASS 3 DRUG.
- For urinary incontinence, or as a decongestant Β· 0.2-0.4 mg/kg [or practically, 15-60 mg (total dose) per dog] Β· PO Β· q8-12h
- To increase urethral tone Β· 1.5 mg/kg Β· PO Β· two to three times a day
- For retrograde ejaculation Β· 4-5 mg/kg Β· PO Β· three times daily or 1 to 3 hours before semen collection or attempted breeding may be tried.
μ©λμ λ©΄ν μμ μ λ¬Έκ°λ₯Ό μν μμ μ°Έκ³ μλ£μ λλ€. νμ μ΅μ λΌλ²¨κ³Ό κ°λ³ νμμ λν΄ νμΈνμμμ€.
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- Glaucoma
- Prostatic hypertrophy
- Hyperthyroidism
- Diabetes mellitus
- Cardiovascular disorders
- Hypertension
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- Panting
- Decreased appetite
- Lethargy
- Tachycardia
- CNS excitement
- Restlessness
- Insomnia
- Hypertension
- Arrhythmias
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- Monoamine Oxidase (MAO) Inhibitors (e.g., amitraz, selegiline) Β· Should not be given within two weeks of receiving MAOIs; risk of severe hypertension and toxicity.
- Reserpine Β· Increased chance of hypertension if given concomitantly.
- Other Sympathomimetic Agents (e.g., ephedrine, phenylpropanolamine) Β· Increased toxicity may result; should not be administered together.
- Tricyclic Antidepressants (e.g., clomipramine, amitriptyline) Β· Increased chance of hypertension if given concomitantly.
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- Efficacy (improvement in incontinence or congestion)
- Heart rate
- CNS stimulation (restlessness, agitation)
- Appetite
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Overdoses of pseudoephedrine can cause **hyperthermia, mydriasis, tachycardia, hypertension, vomiting, disorientation, and seizures**. * **Toxicity Thresholds:** In small animals, adverse reactions may develop at doses of 5-6 mg/kg. Deaths have occurred at doses >10-12 mg/kg. * **Clinical Signs:** Common findings in dogs include hyperactivity, tachycardia, agitation, mydriasis, restlessness, head bobbing, and panting. Cats commonly present with tachycardia. * **Treatment:** Large overdoses should be treated with gastric evacuation (if not contraindicated). Treat supportively and symptomatically (e.g., propranolol for tachycardia). Phenothiazines are preferred to treat hyperactivity, agitation, and tremors as diazepam may worsen dysphoria. Contact an animal poison control center for further guidance.
VetSheet μ½λ¬Ό λ νΌλ°μ€λ λ©΄ν μμ μ λ¬Έκ°λ₯Ό μν μμ μμ¬κ²°μ 보쑰 λꡬμ΄λ©°, μ λ¬Έμ νλ¨μ΄λ μ μ‘°μ¬μ μ΅μ λΌλ²¨μ λμ νμ§ μμ΅λλ€.