νΌλν
**νΌλν (Pyrantel)**μ μμνμμ μμ₯κ΄ μ μΆ©λ₯, νΉν νμΆ© λ° κ΅¬μΆ©μ ꡬμ νκΈ° μν΄ λ리 μ¬μ©λλ κ΄λ²μ ꡬ좩μ μ λλ€. νΈμΆ©μ λν ꡬ좩 λ²μλ₯Ό λνκΈ° μν΄ **νλ°ν (Febantel)**μ΄λ **μ₯μ°ν (Oxantel)**κ³Ό μμ£Ό νΌν©λκ±°λ, μ΄μΆ©μ νμ μΌλ‘ νκΈ° μν΄ νλΌμ§μ½΄ν κ³Ό νΌν©λμ΄ μ¬μ©λ©λλ€. > **μμ ν:** νΌλν μ μμ₯κ΄μμ κ±°μ ν‘μλμ§ μμ΅λλ€. μ΄λ¬ν μ½λνμ νΉμ±μ νμ κΈ°μμΆ©μ΄ μμνλ μ₯ λ΄κ°μμ λμ λλλ₯Ό μ μ§νκ² νλ λμμ μ μ λ ΈμΆμ μ΅μννμ¬ μμ£Όμκ² λμ μμ μ±μ μ 곡νλ―λ‘ λ§€μ° μ μ΅ν©λλ€.
μμ© κΈ°μ : Pyrantel acts as a **depolarizing neuromuscular blocking agent** in susceptible parasites. It functions as a **cholinergic agonist** at the nicotinic acetylcholine receptors of the nematode β causes continuous depolarization of the parasite's muscle cell membrane β results in **spastic paralysis** of the worm. The paralyzed parasites lose their attachment to the intestinal wall and are subsequently expelled from the host's gastrointestinal tract via normal peristalsis.
λλ¬Ό μ’ λ³ μ©λ
- Control of Toxocara canis, Toxascaris leonina, Trichuris vulpis, Uncinaria stenocephala, and Ancylostoma caninum Β· 5 mg/kg pyrantel + 15 mg/kg febantel or 20 mg/kg oxantel Β· PO Β· repeat as required Β· Single dose, repeat as required Β· Often administered as a combination product.
- Control of susceptible gastrointestinal nematodes Β· 57.5 mg/kg pyrantel embonate Β· PO Β· repeat as required Β· Single dose, repeat as required Β· Equivalent to approximately 20 mg/kg pyrantel base.
μ©λμ λ©΄ν μμ μ λ¬Έκ°λ₯Ό μν μμ μ°Έκ³ μλ£μ λλ€. νμ μ΅μ λΌλ²¨κ³Ό κ°λ³ νμμ λν΄ νμΈνμμμ€.
ν¬μ¬ κ²½λ‘
κΈκΈ°
- Puppies < 2 months of age
- Puppies < 1 kg body weight
- Pregnant animals (safety not established)
- Lactating animals (safety not established)
μ΄μλ°μ
- Vomiting
- Diarrhoea
μ½λ¬Ό μνΈμμ©
- Febantel Β· Synergistic effect against whipworms Β· null
- Oxantel Β· Synergistic effect against whipworms Β· null
- Piperazine Β· Antagonistic mechanisms of action (piperazine causes flaccid paralysis, pyrantel causes spastic paralysis) Β· major
- Levamisole Β· Similar mechanism of action; concurrent use increases the risk of cholinergic toxicity Β· major
- Cholinesterase inhibitors Β· Increased risk of cholinergic toxicity Β· major
λͺ¨λν°λ§
- Resolution of clinical signs (e.g., diarrhea, poor weight gain)
- Fecal flotation/egg counts to confirm parasite clearance
κ³Όμ©λ
Due to its poor gastrointestinal absorption, pyrantel has a wide margin of safety. Massive overdosage may result in systemic cholinergic signs, including **salivation, vomiting, tremors, ataxia, and dyspnea**. Treatment is supportive and symptomatic.
VetSheet μ½λ¬Ό λ νΌλ°μ€λ λ©΄ν μμ μ λ¬Έκ°λ₯Ό μν μμ μμ¬κ²°μ 보쑰 λꡬμ΄λ©°, μ λ¬Έμ νλ¨μ΄λ μ μ‘°μ¬μ μ΅μ λΌλ²¨μ λμ νμ§ μμ΅λλ€.