피란텔 파모산염
Pyrantel Pamoate
Pyrantel pamoate
다른 이름: Strongid T · Strongid Paste · Strongid C · Nemex-2 · Drontal Plus · Heartgard Plus · Tri-Heart Plus · Virbantel · Reese's Pinworm · Pin-X · CP-10423-16 · pyrantel embonate · pirantel pamoate
VetSheet 수의사 팀 검수업데이트 2026년 4월 5일근거 기반 수의학 참고자료
용량은 수의사 전문가를 위한 임상 참고자료입니다. 반드시 최신 약물 정보 및 개별 환자에 따라 확인하시기 바랍니다.
동물 종별 용량
🌎 NA — North America🌍 EU — Europe
개
| 적응증 | 용량 | 경로 | 빈도 | 기간 | 지역 |
|---|---|---|---|---|---|
| For susceptible parasites | For dogs weighing <5 lb: 10 mg/kg (as base) PO; for dogs weighing >5 lbs: 5 mg/kg (as base) PO. Treat puppies at 2, 3, 4, 6, 8, and 10 weeks of age. Treat lactating bitches 2-3 weeks after whelping. Do follow-up fecal 2-4 weeks after treating to determine need for retreatment. | PO | See dose | — | 🌎 NA |
| For hookworms, or roundworms | 5 mg/kg PO after meals; repeat in 7-10 days | PO | repeat in 7-10 days | — | 🌎 NA |
| Puppies | 5-10 mg/kg PO; can be repeated every 2-3 weeks until at least 12 weeks of age. | PO | every 2-3 weeks | until at least 12 weeks of age | 🌎 NA |
| For susceptible parasites | 20 mg/kg PO; be sure that liquid is well mixed before using; tablets may be broken for accurate dosing. | PO | Single dose | — | 🌎 NA |
- Puppies: Can be treated as early as 2-3 weeks of age
- For susceptible parasites: Not FDA-approved for cats but very safe and effective.
고양이
| 적응증 | 용량 | 경로 | 빈도 | 기간 | 지역 |
|---|---|---|---|---|---|
| For susceptible parasites using combination product with praziquantel (Drontal) | Administer a minimum dose of 2.27 mg praziquantel and 9.2 mg pyrantel pamoate per pound of body weight according to the dosing tables on labeling. | PO | Single dose | — | 🌎 NA |
| Ascarids, Hookworms, Physaloptera | 5 mg/kg, PO; repeat in 2 weeks (one time only for Physaloptera) | PO | repeat in 2 weeks | — | 🌎 NA |
| For susceptible parasites | 10 mg/kg PO, repeat in 3 weeks | PO | repeat in 3 weeks | — | 🌎 NA |
| Kittens | 5-10 mg/kg PO; can be repeated every 2-3 weeks until at least 12 weeks of age. | PO | every 2-3 weeks | until at least 12 weeks of age | 🌎 NA |
- For susceptible parasites using combination product with praziquantel (Drontal): May be given directly by mouth or in a small amount of food. Do not withhold food prior to or after treatment. If reinfection occurs, treatment may be repeated.
- Kittens: Can be treated as early as 2-3 weeks of age
소형 포유류
| 적응증 | 용량 | 경로 | 빈도 | 기간 | 지역 |
|---|---|---|---|---|---|
| Rabbits: For susceptible parasites | 15-10 mg/kg PO, repeat in 2-3 weeks | PO | repeat in 2-3 weeks | — | 🌎 NA |
| Llamas: For susceptible parasites | 18 mg/kg, PO for one day | PO | Single dose | 1 day | 🌎 NA |
새
| 적응증 | 용량 | 경로 | 빈도 | 기간 | 지역 |
|---|---|---|---|---|---|
| Psittacines: In endemic areas, outdoor breeding birds and their offspring should be routinely dewormed for ascarids | 25 mg/kg PO q2 weeks. | PO | q2 weeks | — | 🌎 NA |
| For intestinal nematodes | 100 mg/kg, PO as a single dose in psittacines and passerines | PO | Single dose | — | 🌎 NA |
말
| 적응증 | 용량 | 경로 | 빈도 | 기간 | 지역 |
|---|---|---|---|---|---|
| For susceptible parasites | 6.6 mg/kg PO every 6-8 weeks for ascarid control in foals and every 4 weeks for ascarid control on some farms. For tapeworm control, double the dose (13.2 mg/kg PO) and use once to twice yearly. | PO | every 4-8 weeks or 1-2x yearly | — | 🌎 NA |
| For susceptible parasites | 6.6 mg (as base)/kg PO; 13.2 mg (as base)/kg for cestodes | PO | Single dose | — | 🌎 NA |
소
| 적응증 | 용량 | 경로 | 빈도 | 기간 | 지역 |
|---|---|---|---|---|---|
| For susceptible parasites | Pyrantel tartrate: 25 mg/kg, PO | PO | Single dose | — | 🌎 NA |
돼지
| 적응증 | 용량 | 경로 | 빈도 | 기간 | 지역 |
|---|---|---|---|---|---|
| To remove Ascaris suum or Oesophagostomum spp. | Pyrantel tartrate: 22 mg/kg PO (or in feed at a rate of 800 grams/ton) as a single treatment. For Ascaris suum only: in feed at a rate of 96 grams/ton (2.6 mg/kg) for 3 days. | PO | Single dose or 3 days | 1-3 days | 🌎 NA |
| For ascarids and nodular worms in potbellied pigs | 6.6 mg/kg PO | PO | Single dose | — | 🌎 NA |
- To remove Ascaris suum or Oesophagostomum spp.: Label instructions from several pyrantel tartrate premix products
양
| 적응증 | 용량 | 경로 | 빈도 | 기간 | 지역 |
|---|---|---|---|---|---|
| For susceptible parasites | Pyrantel tartrate: 25 mg/kg, PO | PO | Single dose | — | 🌎 NA |
염소
| 적응증 | 용량 | 경로 | 빈도 | 기간 | 지역 |
|---|---|---|---|---|---|
| For susceptible parasites | Pyrantel tartrate: 25 mg/kg, PO | PO | Single dose | — | 🌎 NA |
용량은 수의사 전문가를 위한 임상 참고자료입니다. 반드시 최신 약물 정보 및 개별 환자에 따라 확인하시기 바랍니다.
개요
피란텔 파모산염은 널리 사용되며 매우 안전한 피리미딘계 구충제로, 다양한 동물의 장내 선충(회충 및 구충)에 주로 효과적입니다.
파모산염은 위장관에서 거의 흡수되지 않기 때문에, 표적 기생충이 서식하는 장 내강에서 높은 농도를 달성합니다. 안전역이 매우 넓고 기호성이 좋은 현탁액 형태로 제공되어 소아 수의학(강아지 및 고양이의 정기 구충)에서 필수적인 약물입니다.
임상 팁: 회충과 구충에는 매우 효과적이지만, 표준 용량의 피란텔은 편충(Trichuris spp.)과 대부분의 촌충에는 효과가 없습니다. 그러나 말의 경우 맹장 촌충(Anoplocephala perfoliata)을 구제하기 위해 두 배 용량을 사용합니다. 말의 원충 및 개의 구충(Ancylostoma caninum)에서 내성 발생이 임상적으로 새로운 문제로 대두되고 있습니다.
작용 기전
Pyrantel acts as a depolarizing neuromuscular blocking agent in susceptible parasites.
- It binds selectively to nicotinic acetylcholine receptors on the somatic muscle cells of the nematode.
- This binding causes continuous depolarization and an influx of calcium → spastic paralysis of the worm.
- Paralyzed worms lose their ability to maintain attachment to the host's intestinal mucosa and are subsequently expelled alive in the feces via normal gastrointestinal peristalsis.
- It also possesses mild cholinesterase inhibitory properties, further contributing to the accumulation of acetylcholine at the parasite's neuromuscular junction.
안전성·주의사항
금기사항
- Severely debilitated animals
부작용
- Emesis (rare, primarily in small animals)
주의
Use with caution in severely debilitated animals. The drug is considered very safe for use during pregnancy (Class A in dogs/cats) and is safe to use in nursing veterinary patients.
약물 상호작용
Increased risk for adverse effects
Because of similar mechanisms of action (and toxicity), do not use concurrently
Because of similar mechanisms of action (and toxicity), do not use concurrently
Increased risk for adverse effects
Pyrantel and piperazine have antagonistic mechanisms of action; do not use together
모니터링
- Fecal egg count reduction testing (FECRT) for strongyle nematodes (especially in horses to monitor for resistance)
- Resolution of clinical signs of parasitism
- Routine fecal flotations 2-4 weeks post-treatment
약동학
흡수
Pyrantel pamoate is poorly absorbed from the GI tract, allowing it to reach the lower GI in dogs, cats, and equines. Pyrantel tartrate is absorbed more readily than the pamoate salt. Pigs and dogs absorb pyrantel tartrate more so than ruminants, with peak plasma levels occurring 2-3 hours after administration.
분포
Acts primarily locally within the gastrointestinal lumen due to poor systemic absorption of the pamoate salt.
대사
The fraction of the drug that is absorbed is rapidly metabolized.
배설
Excreted into the urine and feces.
과다투여
Pyrantel has a moderate to wide margin of safety.
- Dosages up to approximately 7 times the recommended dose generally result in no toxic reactions.
- In horses, doses of 20X yielded no adverse effects.
- The LD50 in mice and rats for pyrantel tartrate is 170 mg/kg; >690 mg/kg for pyrantel pamoate in dogs.
- Chronic dosing of pyrantel pamoate in dogs resulted in clinical signs when given at 50 mg/kg/day, but not at 20 mg/kg/day over 3 months.
- Clinical signs of toxicity may include increased respiratory rates, profuse sweating (in species with sweat glands), ataxia, or other cholinergic effects.
제품
제형
- Tablets
- Oral suspension
- Oral paste
- Top dress (granules/pellets)
- Soft-gel capsules
동물용의약품
- Pyrantel Pamoate Tablets: 22.7 mg, 113.5 mg (Nemex Tabs)
- Pyrantel Pamoate Oral Suspension: 4.54 mg/mL (Nemex-2)
- Pyrantel Pamoate Oral Suspension: 50 mg/mL (Strongid T)
- Pyrantel Pamoate Oral Paste: 43.9% w/w (180 mg/mL) (Strongid Paste)
- Pyrantel Tartrate 1.06% Top Dress: 4.8 grams/lb (Strongid C)
- Combination Tablets: Praziquantel/Pyrantel pamoate (Drontal for Cats)
- Combination Chewables: Praziquantel/Pyrantel pamoate (Virbantel)
- Combination Tablets: Praziquantel/Pyrantel pamoate/Febantel (Drontal Plus for Dogs)
- Combination Chewables: Ivermectin/Pyrantel (Heartgard Plus, Tri-Heart Plus)
인용의약품
- Pyrantel Pamoate Oral Suspension: 50 mg/mL & 144 mg/mL (Reese's Pinworm, Pin-X)
- Pyrantel Soft-gel Oral Capsules: 180 mg (Pin-Rid, Reese's Pinworm)
- Pyrantel Pamoate Oral Tablets: 180 mg & 720.5 mg chewable (Reese's Pinworm, Pin-X)
규제 현황
규제 데이터 없음: 🇺🇸 US · 🇪🇺 EU · 🇬🇧 UK · 🇭🇰 HK · 🇹🇼 TW · 🇯🇵 JP · 🇰🇷 KR · 🇦🇺 AU
보관·안정성
Pyrantel pamoate products should be stored in tight, light-resistant containers at room temperature (15-30°C) unless otherwise directed by the manufacturer.
보호자 정보
- 약물 성분이 병 바닥에 가라앉으므로, 용량을 뽑기 전에 현탁액을 충분히 흔들어 주십시오.
- 직접 입으로 투여하거나 소량의 음식에 섞어 먹일 수 있습니다. 투약 전후로 금식할 필요가 없습니다.
- 투약 후 24~48시간 이내에 반려동물의 대변에서 온전하거나 죽은 기생충이 보일 수 있습니다. 이는 정상적인 현상이며 약이 효과가 있음을 나타냅니다.
- 이 약은 매우 어린 강아지와 고양이에게도 매우 안전합니다. 부작용은 매우 드물지만 간혹 구토가 발생할 수 있습니다.
- 1회 투여로는 이동 중인 유충 단계를 죽일 수 없으므로, 수의사가 권장하는 재투여 일정을 반드시 따르십시오.
VetSheet 의약품 참고자료는 수의사 전문가의 임상 의사결정 지원을 위한 것이며, 전문적 판단이나 제조사의 최신 약물 정보를 대체할 수 없습니다.