피리독신 (비타민 B6)

영양성 B군 비타민 / 해독제

**피리독신(비타민 B6)**은 수많은 대사 과정에 필수적인 수용성 비타민입니다. 수의학에서 주요 특정 적응증은 이소니아지드(INH) 또는 크리미딘 중독의 **해독제**로 사용되거나, 리포솜 독소루비신(**Doxil®**)과 관련된 피부 독성(수족증후군)을 지연시키는 것입니다. *임상 팁*: 균형 잡힌 상업용 사료를 섭취하는 개와 고양이에서 식이 결핍은 극히 드물지만, 심각한 위장관 질환이 있는 고양이는 피리독신 요구량이 증가할 수 있습니다. 또한, 시험관 내 연구에 따르면 피리독신은 고양이 유선 종양의 성장을 억제할 수 있는 것으로 나타났습니다.

작용 기전: Pyridoxine is converted in erythrocytes to **pyridoxal phosphate** and, to a lesser extent, **pyridoxamine**, which act as vital coenzymes for protein, lipid, and carbohydrate utilization. * **Neurotransmitter Synthesis**: Required for the synthesis of **GABA** (gamma-aminobutyric acid) in the CNS, and the conversion of tryptophan → **serotonin** or niacin. * **Metabolic Pathways**: Essential for glycogen breakdown, heme synthesis, and the conversion of oxalate → glycine. * **Toxicity Antidote**: Acts as an antidote by directly enhancing the renal excretion of cycloserine and isoniazid.

동물 종별 용량

Cats

To replace pyridoxine antagonized by crimidine ingestion · 20 mg/kg · IV · Once

Dogs

Isoniazid (INH) toxicity · If quantity of INH ingested is known, give pyridoxine on a mg for mg (1:1) basis. If it is not known, give pyridoxine initially at 71 mg/kg as a 5-10% IV infusion over 30-60 minutes · IV · Once · Some sources say it can be given as an IV bolus. Do not use injectable B-complex vitamins.
To replace pyridoxine antagonized by crimidine ingestion · 20 mg/kg · IV · Once
To delay the development of cutaneous toxicity (PPES) associated with doxorubicin containing pegylated liposomes (Doxil®) · 50 mg · PO · q8h (three times daily) · During chemotherapy protocol period

용량은 면허 수의 전문가를 위한 임상 참고 자료입니다. 항상 최신 라벨과 개별 환자에 대해 확인하십시오.

투여 경로

POIV

금기

Documented hypersensitivity or sensitivity to pyridoxine

이상반응

Paresthesias (reported in humans)
Somnolence (reported in humans)
Reduced serum folic acid levels
Peripheral neuropathy (associated with massive overdoses)

약물 상호작용

Chloramphenicol · May cause increased pyridoxine requirements
Estrogens · May cause increased pyridoxine requirements
Hydralazine · May cause increased pyridoxine requirements
Immunosuppressants (e.g., azathioprine, chlorambucil, cyclophosphamide, corticosteroids) · May cause increased pyridoxine requirements
Isoniazid · May cause increased pyridoxine requirements
Penicillamine · May cause increased pyridoxine requirements
Levodopa · Pyridoxine may reduce levodopa efficacy (no interaction when levodopa is used with carbidopa)
Phenobarbital · High dose pyridoxine may decrease phenobarbital serum levels
Phenytoin · High dose pyridoxine may decrease phenytoin serum concentration

모니터링

Efficacy for intended use
Neurologic signs (gait, coordination) if on high doses

과용량

> **Warning**: While single overdoses are generally not problematic unless massive, chronic high doses can cause severe neurologic toxicity. * **Massive Acute Overdose**: Laboratory animals given 3-4 grams/kg developed seizures and died. * **Chronic Overdose**: Dogs (Beagles) repeatedly given 3 gram oral daily doses developed uncoordinated gait and neurologic signs. Neuronal lesions were noted in sensory, dorsal root ganglia, and trigeminal ganglia. Signs generally resolved over a 2-month drug-free period.

VetSheet 약물 레퍼런스는 면허 수의 전문가를 위한 임상 의사결정 보조 도구이며, 전문적 판단이나 제조사의 최신 라벨을 대신하지 않습니다.