퀴나크린

동물 종별 용량

용량은 면허 수의 전문가를 위한 임상 참고 자료입니다. 항상 최신 라벨과 개별 환자에 대해 확인하십시오.

투여 경로

금기

• Hepatic dysfunction (relative)
• Pregnancy (relative, potential teratogen)
• Psychotic disorders (in humans)
• Psoriasis (in humans)
• Porphyria (in humans)

이상반응

• Yellowing of skin and urine (benign)
• Anorexia
• Nausea and vomiting
• Diarrhea
• Abnormal behaviors ('fly biting', agitation)
• Lethargy
• Pruritus
• Fever
• Hypersensitivity reactions (rare)
• Hepatopathy (rare)
• Aplastic anemia (rare)
• Corneal edema (rare)
• Retinopathy (rare)

약물 상호작용

• Alcohol · May cause a 'disulfiram-like' reaction if used concurrently.
• Hepatotoxic Drugs · Quinacrine concentrates in the liver; use with caution with other hepatotoxic agents.
• Primaquine · Quinacrine increases the toxicity of primaquine; do not use simultaneously.

모니터링

• Efficacy (fecal exams, reduction in diarrhea)
• Adverse effects (GI upset, behavioral changes)

과용량

**Acute Toxicity:** Overdosage can be severe and potentially fatal. * **Clinical Signs**: CNS excitation (including seizures), severe GI disturbances, vascular collapse, and cardiac arrhythmias. * **Treatment**: * Gut emptying protocols (emesis/lavage, activated charcoal). * Supportive and symptomatic therapies. * Urinary acidification (e.g., with ammonium chloride) and forced diuresis with adequate fluid therapy to enhance renal excretion.