라미프릴

동물 종별 용량

용량은 면허 수의 전문가를 위한 임상 참고 자료입니다. 항상 최신 라벨과 개별 환자에 대해 확인하십시오.

투여 경로

금기

• Hypersensitivity to ACE inhibitors
• Clinical cases of vascular stenosis (e.g., aortic stenosis)
• Obstructive hypertrophic cardiomyopathy
• Concurrent use with potassium-sparing diuretics (per UK label)

이상반응

• Anorexia
• Vomiting
• Diarrhea
• Weakness
• Hypotension
• Hyperkalemia

약물 상호작용

• Aspirin · May potentially negate the decrease in systemic vascular resistance induced by ACE inhibitors (though low-dose aspirin did not affect enalaprilat hemodynamics in one dog study).
• Antidiabetic agents (insulin, oral agents) · Possible increased risk for hypoglycemia; enhanced monitoring recommended.
• Diuretics (e.g., furosemide, hydrochlorothiazide) · Potential for increased hypotensive effects.
• Diuretics, potassium sparing (e.g., spironolactone, triamterene) · Increased hyperkalemic effects; enhanced monitoring of serum potassium required.
• NSAIDs · Potential for increased risk of renal dysfunction or hyperkalemia.
• Potassium supplements · Increased risk for hyperkalemia.

모니터링

• Clinical signs of CHF
• Serum electrolytes (especially potassium)
• Creatinine and BUN
• Urine protein
• CBC with differential (periodic)
• Blood pressure (if treating hypertension or if clinical signs of hypotension arise)

과용량

Ramipril appears quite safe in dogs; dosages as high as 1 gram/kg induced only mild GI distress. Lethal doses in rodents are extremely high (10-11 grams/kg). * **Primary concern:** Hypotension. * **Treatment:** Supportive treatment with volume expansion (normal saline) is recommended to correct blood pressure. * **Note:** Because of the drug's long duration of action, prolonged monitoring and treatment may be required.