로피바카인

국소 마취제

로피바카인은 신경 차단, 국소 및 경막외 마취 기법을 통한 진통 제공에 사용되는 지속성 아미드계 국소 마취제입니다. 부피바카인에 비해 심장 독성이 적고 운동 신경보다 감각 신경에 대한 선택성이 높아 운동 신경 차단 정도를 줄여줍니다. 치료가 어려운 심각한 부정맥을 유발할 수 있으므로 정맥 주사는 절대 금해야 합니다.

작용 기전: Ropivacaine produces local anesthesia through the **reversible blockade of voltage-gated sodium channels** in nerve fibers. By binding to the intracellular portion of sodium channels, it prevents sodium influx → inhibits depolarization → prevents the generation and conduction of action potentials along the nerve fiber. Its higher lipid solubility allows it to preferentially block A-delta and C fibers (sensory/pain) over A-alpha fibers (motor).

동물 종별 용량

Dogs

Analgesia (perineural, epidural, or intrapleural) · Up to 4 mg/kg · Perineural/Epidural/Intrapleural · q8h · Lower doses should be used when systemic absorption is likely to be high (e.g., intrapleural). Can be diluted with normal saline for wider distribution.

Cats

Analgesia · Maximum 2 mg/kg · Perineural/Epidural/Intrapleural · The toxic dose has not been established in cats; it is recommended not to exceed 2 mg/kg.

용량은 면허 수의 전문가를 위한 임상 참고 자료입니다. 항상 최신 라벨과 개별 환자에 대해 확인하십시오.

투여 경로

EpiduralPerineuralIntrapleural

금기

Intravenous (IV) administration
Intravenous regional anaesthesia (Bier block)

이상반응

Cardiac arrhythmias (if injected intravascularly)
Systemic toxicity (CNS excitation followed by depression, seizures)
Motor blockade (dose-dependent)

약물 상호작용

Other local anaesthetics · Additive systemic toxicity; dose of ropivacaine should be reduced when used in combination. · major
Adrenaline (Epinephrine) · Unlike some other local anesthetics, the addition of adrenaline does not appear to significantly alter the duration of the ropivacaine block. · null

모니터링

Heart rate and rhythm (ECG)
Blood pressure
Signs of CNS toxicity (twitching, tremors, seizures)
Motor function recovery

과용량

Overdosage or inadvertent intravascular injection can lead to severe systemic toxicity. * **Cardiovascular:** May precipitate severe cardiac arrhythmias that are highly refractory to standard treatments, hypotension, and cardiovascular collapse. * **CNS:** May cause excitation, tremors, and seizures, followed by CNS depression. * **Treatment:** Supportive care, oxygen therapy, seizure control (e.g., benzodiazepines), and potentially intravenous lipid emulsion (ILE) therapy for severe toxicity.

VetSheet 약물 레퍼런스는 면허 수의 전문가를 위한 임상 의사결정 보조 도구이며, 전문적 판단이나 제조사의 최신 라벨을 대신하지 않습니다.