셀레길린

동물 종별 용량

용량은 면허 수의 전문가를 위한 임상 참고 자료입니다. 항상 최신 라벨과 개별 환자에 대해 확인하십시오.

투여 경로

금기

• Known sensitivity to selegiline
• Lactating bitches (acts on prolactin secretion)
• Pregnant bitches

이상반응

• No specific adverse reactions are listed in the monograph
• Clinical Pearl: May occasionally cause mild gastrointestinal upset, restlessness, or lethargy

약물 상호작용

• Alpha-2 antagonists · Should not be administered concurrently or within 24 hours before/after use · major
• Pethidine · Contraindicated concurrent use · major
• Ephedrine · Contraindicated concurrent use · major
• Amitraz · Potential MAOI interaction; contraindicated · major
• Phenothiazines · Contraindicated concurrent use · major
• Morphine · Potentiates the effect of morphine · moderate
• Metronidazole · Potential interaction exists · minor
• Prednisolone · Potential interaction exists · minor
• Trimethoprim · Potential interaction exists · minor
• Tricyclic antidepressants (amitriptyline, doxepin, clomipramine) · Do not use selegiline for at least 2-3 weeks after TCA use · major
• Fluoxetine · Do not use selegiline for at least 6 weeks after long-term fluoxetine use · major

모니터링

• Improvement in behavioural signs (anxiety, phobias, social withdrawal)
• Improvement in cognitive function (disorientation, sleep-wake cycle alterations)
• Adverse drug interactions if other medications are introduced

과용량

No specific overdose information is provided in the monograph. **Clinical Pearl:** Overdoses of MAOIs can lead to signs of serotonin syndrome or excessive dopaminergic stimulation, including hyperthermia, tachycardia, tremors, and agitation. Treatment is supportive.