요오드화 나트륨 / 요오드화 칼륨

항진균제 / 영양 보충제

요오드화물은 주로 특정 육아종성 감염 치료를 위해 수의학에서 사용됩니다. 주요 적응증으로는 반추동물의 방선간균증(목설증) 및 방선균증, 말, 개, 고양이의 스포로트릭스증이 있습니다. 간혹 거담제나 요오드 결핍증 보충제로도 사용됩니다. 고양이는 요오드 중독에 매우 민감하므로 고양이에게 사용하는 것은 논란의 여지가 있습니다.

작용 기전: The exact mechanism of action for treating actinobacillosis and sporotrichosis is unknown. * Iodides possess little to no direct *in vitro* antimicrobial or antifungal activity. * They are believed to act by modifying the **granulomatous inflammatory process**. * **Proposed mechanism:** Iodides may enhance **phagocytosis** by macrophages or alter the immune response within granulomas, facilitating the breakdown of granulomatous tissue and allowing the body's immune system to clear the infection.

동물 종별 용량

Sheep

Actinobacillosis · 70 mg/kg IV given as a 10% or 20% solution · IV · repeat at least one more time at a 7-10 day interval · Refractory cases may require more frequent (2-3 day intervals) treatment.

Goats

Actinobacillosis · 70 mg/kg IV given as a 10% or 20% solution · IV · repeat at least one more time at a 7-10 day interval · Refractory cases may require more frequent (2-3 day intervals) treatment.

Cats

Sporotrichosis · 20 mg/kg PO q12-24h · PO · q12-24h · at least 60 days
Sporotrichosis · 20 mg/kg PO q12-24h · PO · q12-24h · Using SSKI; give with food. Itraconazole is less likely to cause adverse effects.

Cattle

Actinobacillosis (woody tongue) · 70 mg/kg IV given as a 10% or 20% solution · IV · repeat at least one more time at a 7-10 day interval · Refractory cases may require more frequent (2-3 day intervals) treatment. Severe cases may require adjunctive antibiotics.

Horses

Sporotrichosis · 20-40 mg/kg PO daily · PO · q24h · several weeks · Sodium iodide
Sporotrichosis · Loading dose of sodium iodide at 20-40 mg/kg IV for 2-5 days, then 20-40 mg/kg PO once daily · IV, PO · q24h · at least 3 weeks after all clinical lesions disappear · May administer via oral syringe or mixed in sweet feed. Topical hot packs of 20% sodium iodide may be used on open wounds.
Conidiobolomycosis · 20% sodium iodide at 44 mg/kg IV for 7 days, then ethylenediamine dihydroiodide at 1.3 mg/kg PO q12h for 4 months, then q24h for 1 year, then once per week · IV, PO · Variable · Over 1 year · Excessive lacrimation occasionally noted, but resolved if the drug was held for one day.

Dogs

Sporotrichosis · 40 mg/kg PO q8h · PO · q8h · at least 60 days · Using SSKI
Sporotrichosis · 40 mg/kg PO q12h · PO · q12h · Using SSKI; give with food. Itraconazole is less likely to have adverse effects.

용량은 면허 수의 전문가를 위한 임상 참고 자료입니다. 항상 최신 라벨과 개별 환자에 대해 확인하십시오.

투여 경로

POIV

금기

Known iodide hypersensitivity
Lactating animals (excreted in milk)
Hyperthyroidism
Renal failure
Severe dehydration
Pregnancy (may cause abortion in cattle)

이상반응

Excessive tearing (epiphora)
Vomiting and nausea
Anorexia / inappetence
Nasal discharge
Muscle twitching
Cardiomyopathy
Scaly haircoats and dandruff
Hyperthermia
Decreased milk production
Decreased weight gain
Coughing
Diarrhea
Goiter (especially in foals from supplemented mares)
Cardiovascular failure (in severe toxicity)

약물 상호작용

Antithyroid medications · Iodides may decrease the efficacy of antithyroid medications.
Thyroid supplements · Iodides may enhance the efficacy of thyroid medications.

모니터링

Clinical efficacy (resolution of granulomatous lesions)
Signs of iodism (excessive tearing, nasal discharge, scaly haircoats/dandruff, hyperthermia, coughing, diarrhea)
Thyroid function (if used long-term)

과용량

Excessive iodine accumulation leads to a toxic syndrome known as **iodism**. * **Clinical Signs:** Excessive tearing (epiphora), vomiting, anorexia, nasal discharge, muscle twitching, cardiomyopathy, scaly haircoats/dandruff, hyperthermia, decreased milk production and weight gain, coughing, inappetence, and diarrhea. * **Species Sensitivity:** Cats are particularly prone to developing iodism. Young animals may be more susceptible than adults. Foals have developed goiter when mares were excessively supplemented. * **Severe Toxicity:** Can progress to depression, hypothermia, and cardiovascular failure.

VetSheet 약물 레퍼런스는 면허 수의 전문가를 위한 임상 의사결정 보조 도구이며, 전문적 판단이나 제조사의 최신 라벨을 대신하지 않습니다.