요오드화 나트륨 / 요오드화 칼륨
Sodium Iodide / Potassium Iodide
Sodium Iodide, Potassium Iodide
다른 이름: SSKI · Iodoject · Pima · Thyrosafe · Iosat · Potassium Iodide · Sodium Iodide · Ethylenediamine dihydroiodide · EDDI
VetSheet 수의사 팀 검수업데이트 2026년 4월 5일근거 기반 수의학 참고자료
용량은 수의사 전문가를 위한 임상 참고자료입니다. 반드시 최신 약물 정보 및 개별 환자에 따라 확인하시기 바랍니다.
동물 종별 용량
🌎 NA — North America🌍 EU — Europe
개
| 적응증 | 용량 | 경로 | 빈도 | 기간 | 지역 |
|---|---|---|---|---|---|
| Sporotrichosis | 40 mg/kg PO q8h | PO | q8h | at least 60 days | 🌎 NA |
| Sporotrichosis | 40 mg/kg PO q12h | PO | q12h | — | 🌎 NA |
- Sporotrichosis: Using SSKI
- Sporotrichosis: Using SSKI; give with food. Itraconazole is less likely to have adverse effects.
고양이
| 적응증 | 용량 | 경로 | 빈도 | 기간 | 지역 |
|---|---|---|---|---|---|
| Sporotrichosis | 20 mg/kg PO q12-24h | PO | q12-24h | at least 60 days | 🌎 NA |
| Sporotrichosis | 20 mg/kg PO q12-24h | PO | q12-24h | — | 🌎 NA |
- Sporotrichosis: Using SSKI; give with food. Itraconazole is less likely to cause adverse effects.
말
| 적응증 | 용량 | 경로 | 빈도 | 기간 | 지역 |
|---|---|---|---|---|---|
| Sporotrichosis | 20-40 mg/kg PO daily | PO | q24h | several weeks | 🌎 NA |
| Sporotrichosis | Loading dose of sodium iodide at 20-40 mg/kg IV for 2-5 days, then 20-40 mg/kg PO once daily | IV, PO | q24h | at least 3 weeks after all clinical lesions disappear | 🌎 NA |
| Conidiobolomycosis | 20% sodium iodide at 44 mg/kg IV for 7 days, then ethylenediamine dihydroiodide at 1.3 mg/kg PO q12h for 4 months, then q24h for 1 year, then once per week | IV, PO | Variable | Over 1 year | 🌎 NA |
- Sporotrichosis: Sodium iodide
- Sporotrichosis: May administer via oral syringe or mixed in sweet feed. Topical hot packs of 20% sodium iodide may be used on open wounds.
- Conidiobolomycosis: Excessive lacrimation occasionally noted, but resolved if the drug was held for one day.
소
| 적응증 | 용량 | 경로 | 빈도 | 기간 | 지역 |
|---|---|---|---|---|---|
| Actinobacillosis (woody tongue) | 70 mg/kg IV given as a 10% or 20% solution | IV | repeat at least one more time at a 7-10 day interval | — | 🌎 NA |
- Actinobacillosis (woody tongue): Refractory cases may require more frequent (2-3 day intervals) treatment. Severe cases may require adjunctive antibiotics.
양
| 적응증 | 용량 | 경로 | 빈도 | 기간 | 지역 |
|---|---|---|---|---|---|
| Actinobacillosis | 70 mg/kg IV given as a 10% or 20% solution | IV | repeat at least one more time at a 7-10 day interval | — | 🌎 NA |
- Actinobacillosis: Refractory cases may require more frequent (2-3 day intervals) treatment.
염소
| 적응증 | 용량 | 경로 | 빈도 | 기간 | 지역 |
|---|---|---|---|---|---|
| Actinobacillosis | 70 mg/kg IV given as a 10% or 20% solution | IV | repeat at least one more time at a 7-10 day interval | — | 🌎 NA |
- Actinobacillosis: Refractory cases may require more frequent (2-3 day intervals) treatment.
용량은 수의사 전문가를 위한 임상 참고자료입니다. 반드시 최신 약물 정보 및 개별 환자에 따라 확인하시기 바랍니다.
개요
요오드화물은 주로 특정 육아종성 감염 치료를 위해 수의학에서 사용됩니다. 주요 적응증으로는 반추동물의 방선간균증(목설증) 및 방선균증, 말, 개, 고양이의 스포로트릭스증이 있습니다. 간혹 거담제나 요오드 결핍증 보충제로도 사용됩니다. 고양이는 요오드 중독에 매우 민감하므로 고양이에게 사용하는 것은 논란의 여지가 있습니다.
작용 기전
The exact mechanism of action for treating actinobacillosis and sporotrichosis is unknown.
- Iodides possess little to no direct in vitro antimicrobial or antifungal activity.
- They are believed to act by modifying the granulomatous inflammatory process.
- Proposed mechanism: Iodides may enhance phagocytosis by macrophages or alter the immune response within granulomas, facilitating the breakdown of granulomatous tissue and allowing the body's immune system to clear the infection.
안전성·주의사항
금기사항
- Known iodide hypersensitivity
- Lactating animals (excreted in milk)
- Hyperthyroidism
- Renal failure
- Severe dehydration
- Pregnancy (may cause abortion in cattle)
부작용
- Excessive tearing (epiphora)
- Vomiting and nausea
- Anorexia / inappetence
- Nasal discharge
- Muscle twitching
- Cardiomyopathy
- Scaly haircoats and dandruff
- Hyperthermia
- Decreased milk production
- Decreased weight gain
- Coughing
- Diarrhea
- Goiter (especially in foals from supplemented mares)
- Cardiovascular failure (in severe toxicity)
주의
Do NOT inject intramuscularly (IM).
When administering parenterally to horses, give slowly intravenously and with extreme caution, as severe generalized reactions have been reported.
Cats are highly prone to developing iodism (iodide toxicity). Weigh risks versus benefits carefully, especially in pregnant animals, as anecdotal reports suggest it can cause abortion in cattle (FDA Category D in humans).
약물 상호작용
Iodides may decrease the efficacy of antithyroid medications.
Iodides may enhance the efficacy of thyroid medications.
모니터링
- Clinical efficacy (resolution of granulomatous lesions)
- Signs of iodism (excessive tearing, nasal discharge, scaly haircoats/dandruff, hyperthermia, coughing, diarrhea)
- Thyroid function (if used long-term)
약동학
흡수
Rapidly and nearly completely absorbed from the gastrointestinal tract following oral administration.
분포
Widely distributed throughout extracellular fluids. Actively concentrated in the thyroid gland, salivary glands, gastric mucosa, and choroid plexus.
대사
Iodide is not metabolized but is incorporated into thyroid hormones (T3 and T4) in the thyroid gland.
배설
Primarily excreted by the kidneys into the urine. Also excreted in milk, saliva, and tears. Therapeutic efficacy of IV sodium iodide for actinobacillosis is rapid, with beneficial effects usually seen within 48 hours.
과다투여
Excessive iodine accumulation leads to a toxic syndrome known as iodism.
- Clinical Signs: Excessive tearing (epiphora), vomiting, anorexia, nasal discharge, muscle twitching, cardiomyopathy, scaly haircoats/dandruff, hyperthermia, decreased milk production and weight gain, coughing, inappetence, and diarrhea.
- Species Sensitivity: Cats are particularly prone to developing iodism. Young animals may be more susceptible than adults. Foals have developed goiter when mares were excessively supplemented.
- Severe Toxicity: Can progress to depression, hypothermia, and cardiovascular failure.
제품
제형
- Injection: 20% (200 mg/mL)
- Oral solution: 1 g/mL (SSKI)
- Oral syrup: 62.5 mg/mL
- Oral tablets: 65 mg, 130 mg
- Oral powder/granules (Ethylenediamine dihydroiodide)
동물용의약품
- Sodium Iodide Injection: 20 grams/100 mL (20%; 200 mg/mL) in 250 mL vials
- Oral iodide powders/granules (Active ingredient: ethylenediamine dihydroiodide)
인용의약품
- Potassium Iodide Solution (SSKI): 1 gram/mL
- Potassium Iodide Oral Syrup (Pima): 62.5 mg/mL
- Potassium Iodide Oral Tablets: 65 mg, 130 mg (Thyrosafe, Iosat)
규제 현황
규제 데이터 없음: 🇺🇸 US · 🇪🇺 EU · 🇬🇧 UK · 🇭🇰 HK · 🇹🇼 TW · 🇯🇵 JP · 🇰🇷 KR · 🇦🇺 AU
보관·안정성
Store veterinary injectable products at room temperature (15-30°C). Store Supersaturated Potassium Iodide (SSKI) solution below 40°C (preferably 15-30°C) in a tight, light-resistant container; protect from freezing. Crystallization can occur at low temperatures; re-warming and shaking will usually redissolve crystals. If the solution turns brownish-yellow (oxidation), discard it. Physically incompatible with vitamins B and C injection.
보호자 정보
이 약은 맛이 매우 불쾌하므로 개나 고양이에게 경구 투여할 때 음식이나 지방이 많은 액체(전유, 아이스크림 등)와 섞어 먹이면 구역질과 구토를 줄일 수 있습니다. 과도한 눈물, 콧물, 기침, 심한 비듬, 구토 또는 식욕 부진과 같은 요오드 중독 징후가 나타나는지 반려동물을 주의 깊게 관찰하고, 이상이 있으면 즉시 수의사에게 연락하세요. 약물이 모유로 배출되므로 수유 중인 동물에게는 사용하지 마세요.
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