소듐 스티보글루코네이트

동물 종별 용량

용량은 면허 수의 전문가를 위한 임상 참고 자료입니다. 항상 최신 라벨과 개별 환자에 대해 확인하십시오.

투여 경로

금기

• Pre-existing cardiac arrhythmias
• Significantly impaired renal function
• Previous serious adverse reaction to a dose of stibogluconate
• Severe renal impairment
• Severe hepatic impairment

이상반응

• Increased AST levels
• Pain on injection
• Musculoskeletal pain
• Hemolytic anemia
• Leukopenia
• Vomiting
• Diarrhea
• Pancreatitis
• Myocardial injury and arrhythmias
• Renal toxicity
• Shock
• Sudden death
• Thrombophlebitis (with IV administration)
• Nephrotoxicity
• Hepatotoxicity
• Injection site pain
• Lethargy

약물 상호작용

• Amphotericin B · Increased risk of nephrotoxicity · major
• Allopurinol · Synergistic antileishmanial effect (often used together clinically) · minor

모니터링

• CBC
• Liver enzymes (especially AST)
• Renal function tests
• ECG (for myocardial injury/arrhythmias)
• Bone marrow cultures for Leishmania
• Clinical efficacy
• Renal function (BUN, Creatinine, SDMA, Urinalysis)
• Hepatic enzymes (ALT, AST, ALP)
• Pancreatic enzymes (cPLI, Lipase)
• ECG (for arrhythmias)

과용량

In the unlikely event of a parenterally administered overdose, it is suggested to immediately contact an animal poison control center. * **Chelation Therapy:** Potentially, antimony toxicity can be managed by chelating agents such as **dimercaptosuccinic acid (DMSA)** or **d-penicillamine** to enhance excretion.