티오황산나트륨
티오황산나트륨은 수의학에서 주로 **시안화물** 및 **비소** 중독에 사용되는 다목적 해독제입니다. * **시안화물 중독**: 단독으로 또는 아질산나트륨과 함께 사용됩니다. * **중금속 중독**: 비소 또는 구리 중독(몰리브덴산나트륨과 병용)에 사용되지만 비소에 대한 효능은 논란의 여지가 있습니다. * **항암제 일출**: 시스플라틴, 카보플라틴, 닥티노마이신, 독소루비신의 일출로 인한 조직 손상을 완화하는 데 사용됩니다. * **국소 사용**: 곰팡이 감염(백선)에 가끔 사용됩니다.
작용 기전: Sodium thiosulfate acts primarily as an exogenous sulfur donor. * **Cyanide Antidote**: It provides sulfur to the enzyme **rhodanese** (thiosulfate cyanide sulfurtransferase). Rhodanese catalyzes the conversion of highly toxic cyanide → relatively non-toxic **thiocyanate** ion, which is then safely excreted in the urine. * **Heavy Metal Chelation**: The sulfate moiety is presumed to react with and chelate metals like arsenic, facilitating their removal from the body. * **Topical Antifungal**: Activity is likely due to the slow release of colloidal sulfur.
동물 종별 용량
- Copper poisoning · 500 mg sodium thiosulfate in combination with 200 mg ammonium or sodium molybdate PO daily · PO · q24h · up to 3 weeks · Ruminant dose. In conjunction with fluid replacement therapy
- Cyanide toxicity secondary to cyanogenic plants · 660 mg/kg IV sodium thiosulfate in a 30% solution given rapidly using a 12 or 14 gauge needle. · IV · Once · Ruminant dose.
- Arsenic poisoning · 30-60 grams PO every 6 hours for 3-4 days and 30-60 grams as a 10-20% solution IV · PO/IV · q6h · 3-4 days · Ruminant dose. Adjunctive fluid and electrolyte replacement is necessary.
- Copper poisoning · 500 mg sodium thiosulfate in combination with 200 mg ammonium or sodium molybdate PO daily · PO · q24h · up to 3 weeks · Ruminant dose. In conjunction with fluid replacement therapy
- Cyanide toxicity secondary to cyanogenic plants · 660 mg/kg IV sodium thiosulfate in a 30% solution given rapidly using a 12 or 14 gauge needle. · IV · Once · Ruminant dose.
- Arsenic poisoning · 30-60 grams PO every 6 hours for 3-4 days and 30-60 grams as a 10-20% solution IV · PO/IV · q6h · 3-4 days · Ruminant dose. Adjunctive fluid and electrolyte replacement is necessary.
- Cyanide toxicity · Contact an animal poison control center for guidance. · IV · As directed · As directed
- Doxorubicin extravasation · Subcutaneous sodium thiosulfate 2% added to therapy with subcutaneous hydrocortisone and topical betamethasone · SC · Once · Human recommendation extrapolated for veterinary use
용량은 면허 수의 전문가를 위한 임상 참고 자료입니다. 항상 최신 라벨과 개별 환자에 대해 확인하십시오.
투여 경로
금기
- None absolute
이상반응
- Profuse diarrhea (with large oral doses)
약물 상호작용
- Cyanocobalamin · Not compatible when mixed together
모니터링
- Clinical efficacy (resolution of toxicity signs)
- Hydration status (if diarrhea occurs from oral dosing)
과용량
The drug is relatively non-toxic. Large doses by mouth may cause profuse diarrhea. Injectable forms should be given slowly IV.
VetSheet 약물 레퍼런스는 면허 수의 전문가를 위한 임상 의사결정 보조 도구이며, 전문적 판단이나 제조사의 최신 라벨을 대신하지 않습니다.