포도상구균 파지 용해물

면역 자극제 / 생물학적 제제

**포도상구균 파지 용해물(SPL)**은 주로 수의 피부과에서 사용되는 주사형 생물학적 제제 및 면역 자극제입니다. 특히 반려견의 **재발성, 특발성 포도상구균 농피증** 관리에 적응증이 있으며, 종종 적절한 항생제 치료와 병행하여 사용됩니다. > **임상 팁:** 항생제 내성(예: MRSP)이 증가하는 시대에 SPL과 같은 면역 조절제는 전신 항생제 사용 빈도와 기간을 줄이는 데 유용한 보조적 접근법을 제공합니다. 이 제품은 포도상구균 파지를 사용하여 황색포도상구균(Cowan 혈청형 I 및 III; 인간 균주) 배양물을 용해하여 제조됩니다. 준비된 용액에는 황색포도상구균 성분(단백질 A 추출물), 파지 및 여과되지 않은 소 심장 침출액 배지가 포함되어 있으며, 세균학적 무균 상태를 달성하기 위해 한외여과를 거칩니다.

작용 기전: SPL functions as an immunomodulator that specifically enhances **cell-mediated immunity** (Th1 immune response). * **Cytokine Stimulation:** It stimulates the production of key pro-inflammatory and immunoregulatory cytokines, including **Tumor Necrosis Factor (TNF-α)**, **Interleukin-6 (IL-6)**, and **Interferon-gamma (IFN-γ)**. * **Mechanism:** By upregulating IFN-γ and TNF-α, SPL enhances the phagocytic and bactericidal activities of macrophages and neutrophils → leading to improved clearance of intracellular and extracellular staphylococcal organisms from the skin. * **Protein A Role:** The presence of staphylococcal Protein A acts as a potent B-cell superantigen and immunogen, further stimulating a robust host immune response against staphylococcal antigens.

동물 종별 용량

Dogs

Labeled indications (Highly allergic patients) · Skin test with 0.05-0.1 mL intradermally. Therapy: Initially, 0.2 mL SC, then incremental increases of 0.2 mL once a week to 1 mL (a total of 5 injections). Then continue at 1 mL SC weekly for approximately 10-12 weeks. · SC/ID · Weekly · 10-12 weeks · Concomitant antibiotic therapy is recommended for an initial 4-6 week period. Maximum dose should be decreased in small dogs and can be increased cautiously, if necessary, in large dogs to 1.5 mL.
Labeled indications (Non-allergic patients) · 0.5 mL SC twice weekly for 10-12 weeks, then 0.5-1 mL every 1-2 weeks. · SC · Twice weekly then every 1-2 weeks · 10-12 weeks initial, then maintenance · Concomitant antibiotic therapy is recommended for an initial 4-6 week period.
Idiopathic, recurrent pyoderma · 0.5 mL SC twice weekly for 10-12 weeks, then tapered to effect. · SC · Twice weekly · 10-12 weeks then tapered · This agent is rarely needed, because in most cases, an underlying cause can be identified and treated.
Chronic recurrent idiopathic pyoderma · Injections are administered twice weekly (0.5 mL) and slowly reduced to 0.5 mL every 2 weeks. · SC · Twice weekly then reduced · Ongoing · Pyoderma needs to be under control as this product is not a substitute for antibiotics.

용량은 면허 수의 전문가를 위한 임상 참고 자료입니다. 항상 최신 라벨과 개별 환자에 대해 확인하십시오.

투여 경로

SCIntradermal (for skin testing)

금기

Prior systemic hypersensitivity reactions to SPL
Documented hypersensitivity reactions to beef products (contains unfiltered beef heart infusion broth)

이상반응

Post vaccine-type reactions (fever, malaise)
Injection site reactions (redness, itching, swelling occurring 2-3 hours post-injection and persisting up to 3 days)
Systemic hypersensitivity reactions (weakness, vomiting, diarrhea, severe itching, rapid breathing, fatigue/lassitude)

약물 상호작용

Cell-mediated immunosuppressive drugs (e.g., corticosteroids, cyclosporine) · May reduce the efficacy of SPL

모니터링

Clinical efficacy (resolution of pyoderma)
Local injection site reactions (redness, swelling, itching)
Systemic hypersensitivity reactions (anaphylaxis, vomiting, weakness)

과용량

No specific information was located regarding acute toxicity. Other than an increased risk for local or systemic hypersensitivity reactions, significant morbidity appears unlikely. Should an anaphylactic-type reaction occur, treat supportively; the manufacturer recommends **epinephrine** and **atropine** as antidotes.

VetSheet 약물 레퍼런스는 면허 수의 전문가를 위한 임상 의사결정 보조 도구이며, 전문적 판단이나 제조사의 최신 라벨을 대신하지 않습니다.