설파클로르피리다진 나트륨
Sulfachlorpyridazine Sodium
Sulfachlorpyridazine sodium
다른 이름: Vetisulid · cluricol · sulphachlorpyridazine
VetSheet 수의사 팀 검수업데이트 2026년 4월 5일근거 기반 수의학 참고자료
용량은 수의사 전문가를 위한 임상 참고자료입니다. 반드시 최신 약물 정보 및 개별 환자에 따라 확인하시기 바랍니다.
동물 종별 용량
🌎 NA — North America🌍 EU — Europe
새
| 적응증 | 용량 | 경로 | 빈도 | 기간 | 지역 |
|---|---|---|---|---|---|
| Enteric bacterial infections (E. coli) | Mix 1/4 teaspoonful per liter of water and use as only supply of drinking water | PO | continuous | 5-10 days | 🌎 NA |
| Enteric bacterial infections (E. coli) | Mix 3/4 teaspoonsful per 2 quarts of water | PO | continuous | — | 🌎 NA |
| E. coli and coccidiosis in pigeons | 1200 mg per gallon of drinking water | PO | continuous | — | 🌎 NA |
- Enteric bacterial infections (E. coli): Using the oral powder. May be effective for many E. coli enteric infections.
- Enteric bacterial infections (E. coli): Using the oral powder. Fairly effective for enteric infections, particularly E. coli. Reserved for clients who are unable to give other medications by mouth or parenterally.
- E. coli and coccidiosis in pigeons: Very effective for E. coli and it is a good coccidiostat.
소
| 적응증 | 용량 | 경로 | 빈도 | 기간 | 지역 |
|---|---|---|---|---|---|
| Diarrhea caused or complicated by E. coli in calves less than one month of age | 33-49.5 mg/kg PO, or IV twice daily | PO/IV | q12h | 1-5 days | 🌎 NA |
- Diarrhea caused or complicated by E. coli in calves less than one month of age: Suggest initiating therapy with intravenous preparation and then changing to oral if possible
돼지
| 적응증 | 용량 | 경로 | 빈도 | 기간 | 지역 |
|---|---|---|---|---|---|
| Colibacillosis | 44-77 mg/kg PO per day (divide dose and give twice daily if treating individual animals) | PO | q12h or q24h | 1-5 days | 🌎 NA |
용량은 수의사 전문가를 위한 임상 참고자료입니다. 반드시 최신 약물 정보 및 개별 환자에 따라 확인하시기 바랍니다.
개요
설파클로르피리다진 나트륨은 단기~중기 작용을 하는 저지용성 설폰아마이드계 항균제입니다. 수의학에서는 주로 생후 1개월 미만의 송아지와 돼지에서 대장균(E. coli)에 의한 장관계 감염(설사 및 대장균증) 치료에 사용됩니다. 또한 성우 및 기타 동물 종에서 일반적인 목적의 설폰아마이드계 주사제로도 활용됩니다.
임상 요점:
- 시간 의존성, 정균성 항생제이므로 약효를 위해 일정한 투여 간격을 유지하는 것이 매우 중요합니다.
- 설폰아마이드계에 대한 내성이 점차 흔해지고 있으나, 특정 무리 건강 관리(herd health) 적용에는 여전히 가치 있는 약물입니다.
- 일반적인 생리적 pH의 소변에서는 용해도가 높지만, 탈수 환자나 소변이 고도로 농축되고 산성인 경우에는 결정뇨의 위험이 존재합니다.
작용 기전
Sulfonamides are generally bacteriostatic agents. They act as structural analogues of para-aminobenzoic acid (PABA).
- They competitively inhibit the bacterial enzyme dihydropteroate synthase.
- This blocks the incorporation of PABA into dihydropteroic acid → preventing the biosynthesis of tetrahydrofolic acid (the active form of folic acid).
- Because mammalian cells utilize preformed dietary folic acid and do not synthesize their own, they are generally unaffected by this mechanism.
- Efficacy is significantly reduced in the presence of pus, necrotic tissue, or extensive cellular debris, as these environments are rich in PABA which outcompetes the drug.
안전성·주의사항
금기사항
- Hypersensitivity to sulfonamides, thiazides, or sulfonylurea agents
- Severe renal impairment
- Severe hepatic impairment
부작용
- Crystalluria
- Hematuria
- Renal tubule obstruction
- Keratoconjunctivitis sicca (KCS) in dogs
- Bone marrow depression
- Hypersensitivity reactions (rashes, dermatitis)
- Focal retinitis
- Fever
- Vomiting
- Nonseptic polyarthritis
- Muscle weakness, blindness, ataxia, and collapse (with rapid IV injection)
- Tissue irritation and necrosis (with IM or SC injection)
- Temporary depression of normal cellulytic function in the ruminoreticulum
주의
Caution: Use with care in patients with diminished renal or hepatic function, or urinary obstruction.
- Hydration: Ensure adequate urine flow to prevent crystalluria. Alkalinization of urine may prevent crystalluria but decreases tubular reabsorption.
- Administration: Avoid too-rapid IV injection to prevent acute neurological and muscular adverse effects. Avoid IM or SC routes due to the alkaline nature of the solution causing tissue irritation and necrosis.
- Pregnancy: Potentially teratogenic at high doses; crosses the placenta. Weigh risk vs. benefit.
- Lactation: Distributed into milk. Safe use during lactation cannot be assumed; use with caution.
- Laboratory: May cause false-positive results for urine glucose determinations when using the Benedict's method.
약물 상호작용
May decrease the oral bioavailability of sulfonamides if administered concurrently
모니터링
- Clinical efficacy (resolution of diarrhea/infection)
- Adverse effects
- Hydration status and urine output
약동학
흡수
Readily absorbed from the GI tract of non-ruminants. Food delays the rate, but usually not the extent of absorption. Peak levels occur within 1-2 hours in non-ruminant (and young pre-ruminant) animals. Adult ruminants may have significant delays before oral absorption.
분포
Well distributed throughout the body; some reach significant levels in the CSF. Highest levels in liver, kidney, and lung; lower in muscle and bone. Highly bound to serum proteins (species and drug dependent); protein-bound fraction is inactive.
대사
Principally metabolized in the liver via acetylation and glucuronidation, though extra-hepatic metabolism is also involved. Acetylated metabolites may be less soluble, increasing the risk of crystalluria.
배설
Renally excreted via both tubular secretion and glomerular filtration. Protein-bound drug is not filtered. The serum half-life of sulfachlorpyridazine is approximately 1.2 hours in cattle.
과다투여
Acute toxicity secondary to overdoses apparently occurs only rarely in veterinary species.
- Signs of Toxicity: In addition to standard adverse effects, CNS stimulation and myelin degeneration have been noted after very high dosages.
- Treatment: Treatment is largely supportive and symptomatic. Ensure aggressive fluid therapy to maintain urine output and prevent crystalluria.
제품
제형
- Oral powder
- Oral suspension
- Injection
- Oral boluses
동물용의약품
- Sulfachlorpyridazine Sodium Oral powder: 54 grams per bottle (Vetisulid Powder)
- Sulfachlorpyridazine Sodium Oral Suspension: 50 mg/mL in 180 mL bottles (Vetisulid Oral Suspension)
규제 현황
규제 데이터 없음: 🇺🇸 US · 🇪🇺 EU · 🇬🇧 UK · 🇭🇰 HK · 🇹🇼 TW · 🇯🇵 JP · 🇰🇷 KR · 🇦🇺 AU
보관·안정성
Injection: Store at room temperature and protect from light; avoid freezing. Oral suspension: Store at room temperature; avoid freezing. Oral boluses and powder: Store at room temperature; avoid excessive heat (above 40°C; 104°F).
보호자 정보
- 충분한 수분 공급 필수: 약물이 소변에서 결정을 형성(결정뇨)하는 것을 방지하기 위해, 투약 기간 동안 동물이 항상 신선한 물을 마음껏 마실 수 있도록 해주세요. 탈수를 피해야 합니다.
- 정확한 투약: 동물의 상태가 호전된 것처럼 보이더라도, 수의사가 처방한 기간 동안 지시대로 정확히 투여하세요.
- 부작용 관찰: 소변량 감소, 혈뇨, 비정상적인 쇠약 또는 설사 악화가 관찰되면 즉시 수의사에게 연락하세요.
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