설파클로르피리다진 나트륨

설폰아마이드계 항균제

설파클로르피리다진 나트륨은 단기~중기 작용을 하는 저지용성 설폰아마이드계 항균제입니다. 수의학에서는 주로 생후 1개월 미만의 송아지와 돼지에서 **대장균(E. coli)**에 의한 장관계 감염(설사 및 대장균증) 치료에 사용됩니다. 또한 성우 및 기타 동물 종에서 일반적인 목적의 설폰아마이드계 주사제로도 활용됩니다. **임상 요점:** * **시간 의존성, 정균성** 항생제이므로 약효를 위해 일정한 투여 간격을 유지하는 것이 매우 중요합니다. * 설폰아마이드계에 대한 내성이 점차 흔해지고 있으나, 특정 무리 건강 관리(herd health) 적용에는 여전히 가치 있는 약물입니다. * 일반적인 생리적 pH의 소변에서는 용해도가 높지만, 탈수 환자나 소변이 고도로 농축되고 산성인 경우에는 결정뇨의 위험이 존재합니다.

작용 기전: Sulfonamides are generally bacteriostatic agents. They act as structural analogues of para-aminobenzoic acid (PABA). * They competitively inhibit the bacterial enzyme **dihydropteroate synthase**. * This blocks the incorporation of PABA into **dihydropteroic acid** → preventing the biosynthesis of **tetrahydrofolic acid** (the active form of folic acid). * Because mammalian cells utilize preformed dietary folic acid and do not synthesize their own, they are generally unaffected by this mechanism. * Efficacy is significantly reduced in the presence of pus, necrotic tissue, or extensive cellular debris, as these environments are rich in PABA which outcompetes the drug.

동물 종별 용량

Cattle

Diarrhea caused or complicated by E. coli in calves less than one month of age · 33-49.5 mg/kg PO, or IV twice daily · PO/IV · q12h · 1-5 days · Suggest initiating therapy with intravenous preparation and then changing to oral if possible

Birds

Enteric bacterial infections (E. coli) · Mix 1/4 teaspoonful per liter of water and use as only supply of drinking water · PO · continuous · 5-10 days · Using the oral powder. May be effective for many E. coli enteric infections.
Enteric bacterial infections (E. coli) · Mix 3/4 teaspoonsful per 2 quarts of water · PO · continuous · Using the oral powder. Fairly effective for enteric infections, particularly E. coli. Reserved for clients who are unable to give other medications by mouth or parenterally.
E. coli and coccidiosis in pigeons · 1200 mg per gallon of drinking water · PO · continuous · Very effective for E. coli and it is a good coccidiostat.

Swine

Colibacillosis · 44-77 mg/kg PO per day (divide dose and give twice daily if treating individual animals) · PO · q12h or q24h · 1-5 days

용량은 면허 수의 전문가를 위한 임상 참고 자료입니다. 항상 최신 라벨과 개별 환자에 대해 확인하십시오.

투여 경로

POIV

금기

Hypersensitivity to sulfonamides, thiazides, or sulfonylurea agents
Severe renal impairment
Severe hepatic impairment

이상반응

Crystalluria
Hematuria
Renal tubule obstruction
Keratoconjunctivitis sicca (KCS) in dogs
Bone marrow depression
Hypersensitivity reactions (rashes, dermatitis)
Focal retinitis
Fever
Vomiting
Nonseptic polyarthritis
Muscle weakness, blindness, ataxia, and collapse (with rapid IV injection)
Tissue irritation and necrosis (with IM or SC injection)
Temporary depression of normal cellulytic function in the ruminoreticulum

약물 상호작용

Antacids · May decrease the oral bioavailability of sulfonamides if administered concurrently

모니터링

Clinical efficacy (resolution of diarrhea/infection)
Adverse effects
Hydration status and urine output

과용량

Acute toxicity secondary to overdoses apparently occurs only rarely in veterinary species. * **Signs of Toxicity:** In addition to standard adverse effects, **CNS stimulation** and **myelin degeneration** have been noted after very high dosages. * **Treatment:** Treatment is largely supportive and symptomatic. Ensure aggressive fluid therapy to maintain urine output and prevent crystalluria.

VetSheet 약물 레퍼런스는 면허 수의 전문가를 위한 임상 의사결정 보조 도구이며, 전문적 판단이나 제조사의 최신 라벨을 대신하지 않습니다.