타다라필

동물 종별 용량

용량은 면허 수의 전문가를 위한 임상 참고 자료입니다. 항상 최신 라벨과 개별 환자에 대해 확인하십시오.

투여 경로

금기

• Concurrent use of any form of organic nitrates (regularly or intermittently)
• Serious hypersensitivity to tadalafil

이상반응

• Cutaneous flushing of the inguinal region
• Gastrointestinal upset (dyspepsia, nausea)
• Decreased neutrophils and platelets (observed at 4X-18X human equivalent doses; reversible)
• Hypotension (especially if combined with other vasodilators)
• Myalgia or back pain (reported in humans)
• Headache or nasal congestion (reported in humans)

약물 상호작용

• Alpha-adrenergic blockers (e.g., phentolamine, phenothiazines, phenoxybenzamine) · May increase hypotensive effects
• Amlodipine · Potential to increase hypotensive effects
• Antihypertensive / Hypotensive drugs · Potentially could increase hypotensive effects
• Azole antifungals (ketoconazole, itraconazole) · May reduce tadalafil metabolism and increase AUC
• Cimetidine · May reduce tadalafil metabolism and increase AUC
• Erythromycin, Clarithromycin · May reduce tadalafil metabolism and increase AUC
• Nitrates (e.g., Nitroglycerin, Isosorbide) · Significant potentiation of vasodilatory effects; life-threatening hypotension possible
• Nitroprusside sodium · Significant potentiation of vasodilatory effects; life-threatening hypotension possible
• Phenobarbital · May decrease tadalafil concentrations
• Rifampin · May decrease tadalafil concentrations

모니터링

• Clinical efficacy (improved syncope, cough, respiratory effort)
• Pulmonary artery pressure (via echocardiography)
• Systemic blood pressure
• Adverse effects (GI upset, flushing)

과용량

Little information is available for veterinary species. In humans, single doses up to 500 mg and multiple daily doses up to 100 mg produced adverse reactions similar to those seen at lower doses. Overdoses in animals are expected to mirror the drug's adverse effect profile (e.g., severe hypotension, tachycardia, flushing). **Treat supportively** and contact an animal poison control center for guidance.