νμ€λ‘μ
νμ€λ‘μ μ μλ‘μ μ νμ±μ κ°μ§ **μν-1 μλλ λ λ¦° μμ©μ²΄ κΈΈνμ **μ λλ€. μ 립μ , μλ λ° λ°©κ΄κ²½λΆμ ννκ·Όμ μ΄μμμΌ μλ³ λ°°μΆμ λμ΅λλ€. νλΌμ‘°μ (prazosin)μ΄λ νλ Ήμλ²€μλ―Ό(phenoxybenzamine)λ³΄λ€ μμ© μκ°μ΄ κΉλλ€. **μμ ν:** μμνμμλ κΈ°λ₯μ± μμ 체, μ€μ±ννμ§ μμ μμ»· κ°μ μμ± μ 립μ λΉλμ¦(BPH) κ΄λ¦¬ λλ μκ΄κ²°μ/μμ λ°°μΆ λ³΄μ‘°λ₯Ό μν΄ μ€νλΌλ²¨(off-label)λ‘ μμ£Ό μ¬μ©λ©λλ€.
μμ© κΈ°μ : Tamsulosin selectively binds to and blocks **alpha-1A and alpha-1D adrenergic receptors** located predominantly in the smooth muscle of the prostate, prostatic capsule, prostatic urethra, and bladder neck. Blockade of these receptors β relaxation of smooth muscle β decreased urethral resistance β improved urine flow and relief of functional urinary obstruction.
ν¬μ¬ κ²½λ‘
κΈκΈ°
- Hypersensitivity to tamsulosin
- Severe hepatic impairment
- History of orthostatic hypotension
μ΄μλ°μ
- Hypotension
- Lethargy
- Weakness
- Gastrointestinal upset (vomiting, diarrhea)
- Dizziness
μ½λ¬Ό μνΈμμ©
- Other alpha-1 blockers (e.g., prazosin, phenoxybenzamine) Β· Additive hypotensive effects Β· major
- Calcium channel blockers (e.g., amlodipine) Β· Increased risk of hypotension Β· moderate
- Cimetidine Β· Decreased clearance of tamsulosin, potentially increasing plasma concentrations Β· minor
λͺ¨λν°λ§
- Urine output and ease of urination
- Blood pressure
- Renal function
κ³Όμ©λ
Overdosage may lead to severe **hypotension**. Treatment is primarily supportive, including intravenous fluid therapy and potentially vasopressors if hypotension is refractory. Emesis or gastric lavage may be considered if ingestion is recent.
VetSheet μ½λ¬Ό λ νΌλ°μ€λ λ©΄ν μμ μ λ¬Έκ°λ₯Ό μν μμ μμ¬κ²°μ 보쑰 λꡬμ΄λ©°, μ λ¬Έμ νλ¨μ΄λ μ μ‘°μ¬μ μ΅μ λΌλ²¨μ λμ νμ§ μμ΅λλ€.