ํฐ์๋ฏผ (๋นํ๋ฏผ B1)
ํฐ์๋ฏผ(๋นํ๋ฏผ B1)์ ํ์ํ๋ฌผ ๋์ฌ์ ์ ์์ ์ธ ์ ๊ฒฝ ๊ธฐ๋ฅ์ ํ์์ ์ธ ์์ฉ์ฑ ๋นํ๋ฏผ์ ๋๋ค. **์ฃผ์ ์์ ํฌ์ธํธ:** * **๊ฒฐํ ์์ธ:** ์๋๋ฌผ์ ๊ฒฝ์ฐ ์ฃผ๋ก ๋ถ์ ์ ํ ์์ด ์ญ์ทจ(์: ์์์ ๊ฐ ์ฒจ๊ฐ๋์ง ์์ ์ก๋ฅ ์์ฃผ์ ์๋จ, ๊ณ ์ด๋ก ํ๊ดด๋ ์์ ์ฉ ์ฌ๋ฃ) ๋๋ ํฐ์๋ฏธ๋์์ ๊ฐ ํจ์ ๋ ์์(์: ๋ ์์ ) ์ญ์ทจ๋ก ์ธํด ๋ฐ์ํฉ๋๋ค. ๋ฐ์ถ๋๋ฌผ์ ๊ฒฝ์ฐ ํฐ์๋ฏธ๋์์ ๋ฅผ ์์ฑํ๋ ๋ฐ์ถ์ ์ธ๊ท ์ด๋ ๊ณ ์ฌ๋ฆฌ ๊ฐ์ ํฐ์๋ฏธ๋์์ ํจ์ ์๋ฌผ ์ญ์ทจ์ ์ํด ์ด์ฐจ์ ์ผ๋ก ๋ฐ์ํ์ฌ **ํ๋ฐฑ๋์ฐํ์ฆ(PEM)**์ ์ ๋ฐํฉ๋๋ค. * **์์ ์ฆ์:** ์์ฅ๊ด ๋ฌธ์ (์์ ๋ถ์ง, ์ ์ฐ), ์ค์ฆ ์ ๊ฒฝ๊ทผ/์ค์ถ์ ๊ฒฝ๊ณ ์ฆ์(์ด๋ ์ค์กฐ, ๋ฐ์, ๊ณ ์์ด์ ๋ชฉ ๋ณต์ธก ๊ตด๊ณก, ๋ฐ์ฌ ์์ค) ๋๋ ๋ถ์ ๋งฅ์ผ๋ก ๋ํ๋ฉ๋๋ค. * **๋ณด์กฐ์ ์ฉ๋:** **์ํธ๋ ๊ธ๋ฆฌ์ฝ ์ค๋ **(๋ ์ฑ ์ฅ์ด์ฐ์ผ ์์ฑ์ ํผํ๊ธฐ ์ํ ๋์ฌ ๊ฒฝ๋ก ์ฐํ) ๋ฐ **๋ฉ ์ค๋ ** ๊ด๋ฆฌ์ ์์ฃผ ์ฌ์ฉ๋ฉ๋๋ค. * **์์ ํ:** ๋๋ ํ์ํ๋ฌผ ๋์ฌ์ ํฌ๊ฒ ์์กดํ๋ฏ๋ก ์ค์ถ์ ๊ฒฝ๊ณ๋ ํฐ์๋ฏผ ๊ฒฐํ์ ๋งค์ฐ ๋ฏผ๊ฐํ๋ฉฐ, ์ ๊ฒฝ ์ฆ์์ด ๋ํ๋ ๋ ์ ์ํ ๋ณด์ถฉ์ด ํ์์ ์ ๋๋ค.
์์ฉ ๊ธฐ์ : Thiamine is actively transported into cells where it combines with adenosine triphosphate (ATP) to form **thiamine diphosphate (thiamine pyrophosphate or TPP)**. * **Enzymatic Co-factor:** TPP is an essential coenzyme for several key metabolic enzymes, including **pyruvate dehydrogenase**, **alpha-ketoglutarate dehydrogenase** (both critical for the Krebs cycle/aerobic energy production), and **transketolase** (pentose phosphate pathway). * **Metabolic Pathway:** Glucose โ Pyruvate. Without TPP, pyruvate cannot be converted into acetyl-CoA. * **Pathophysiology of Deficiency:** Diminished NADH production forces the cell into anaerobic glycolysis, converting accumulated pyruvic acid into lactic acid โ **Lactic acidosis** and cellular energy failure (especially in high-demand tissues like the brain and heart).
๋๋ฌผ ์ข ๋ณ ์ฉ๋
- Polioencephalomalacia ยท Initially, 10 mg/kg IV; then, 10 mg/kg IM twice daily ยท IV, IM ยท twice daily ยท 2-3 days ยท If no improvement within 4 days, may be advisable to recommend slaughter.
- Thiamine deficiency ยท 20-200 mg ยท IM, SC, or IV ยท Not specified ยท Depending on formulation
- Polioencephalomalacia ยท Initially, 10 mg/kg IV; then, 10 mg/kg IM twice daily ยท IV, IM ยท twice daily ยท 2-3 days ยท If no improvement within 4 days, may be advisable to recommend slaughter.
- Thiamine deficiency ยท 100-250 mg ยท parenterally ยท twice a day ยท Experimentally, as little as 1 mg is effective
- Thiamine deficiency ยท 10-20 mg/kg ยท IM ยท Not specified ยท for several days
- Adjunctive treatment of hepatic lipidosis ยท 100 mg of thiamine in one liter of crystalloid fluids ยท IV ยท Not specified ยท With additional soluble B vitamins. Indicated if neck ventroflexion is present.
- Thiamine deficiency ยท 100-250 mg ยท SC ยท twice daily ยท for several days until regression of symptoms with complete recovery
- Thiamine deficiency ยท 10-20 mg/kg IM or SC two to three times daily until signs abate, then 10 mg/kg PO once daily ยท IM, SC, PO ยท two to three times daily, then once daily ยท 21 days for PO phase
ํฌ์ฌ ๊ฒฝ๋ก
๊ธ๊ธฐ
- Known hypersensitivity to thiamine or any of its components
- Known hypersensitivity to thiamine
์ด์๋ฐ์
- Hypersensitivity or anaphylactic reactions (rare)
- Vasovagal anaphylactic response in cats (cardiac arrest, severe bradycardia, apnea, hypotension, collapse) when given SC (rare)
- Injection site tenderness or muscle soreness (IM)
- Pain at the injection site (IM/SC)
- Anaphylaxis or hypersensitivity reactions (primarily with rapid IV administration)
์ฝ๋ฌผ ์ํธ์์ฉ
- Neuromuscular blocking agents ยท Thiamine may enhance the activity of neuromuscular blocking agents; clinical significance is unknown. ยท minor
๋ชจ๋ํฐ๋ง
- Clinical efficacy (resolution of neurologic, gastrointestinal, or cardiac signs)
- Electrolyte levels (potassium, phosphate, magnesium) if treating conditions like feline hepatic lipidosis
- Resolution of clinical signs of thiamine deficiency (e.g., neurological improvement)
- Dietary intake and nutritional balance
๊ณผ์ฉ๋
Very large doses of thiamine in laboratory animals have been associated with **neuromuscular or ganglionic blockade**, though the clinical significance in veterinary patients is unknown. * **Massive Doses:** May cause hypotension and respiratory depression. * **Lethal Dose:** A lethal dose of 350 mg/kg has been reported. * **Treatment:** Generally, no specific treatment is required for most overdoses due to its water-soluble nature and rapid renal excretion.
VetSheet ์ฝ๋ฌผ ๋ ํผ๋ฐ์ค๋ ๋ฉดํ ์์ ์ ๋ฌธ๊ฐ๋ฅผ ์ํ ์์ ์์ฌ๊ฒฐ์ ๋ณด์กฐ ๋๊ตฌ์ด๋ฉฐ, ์ ๋ฌธ์ ํ๋จ์ด๋ ์ ์กฐ์ฌ์ ์ต์ ๋ผ๋ฒจ์ ๋์ ํ์ง ์์ต๋๋ค.