갑상선 자극 호르몬 (티로트로핀)

동물 종별 용량

용량은 면허 수의 전문가를 위한 임상 참고 자료입니다. 항상 최신 라벨과 개별 환자에 대해 확인하십시오.

투여 경로

금기

• Adrenocortical insufficiency (untreated Addison's disease)
• Hyperthyroidism
• Coronary thrombosis
• Hypersensitivity to bovine thyrotropin or human proteins
• Repeated administration is not advisable
• Patients currently receiving levothyroxine therapy
• Use of chemical grade TSH (due to anaphylaxis risk)

이상반응

• Hypersensitivity reactions (especially with repeated injections of human-derived proteins in animals)
• Clinical signs of hyperthyroidism (with chronic administration or high doses)
• Anaphylactic responses (specifically associated with chemical grade/bovine TSH; recombinant forms are generally well tolerated)

약물 상호작용

• Anabolic or androgenic steroids · May decrease serum T4 levels, making the TSH stimulation test hard to interpret · moderate
• Carbimazole · May decrease serum T4 levels, making the TSH stimulation test hard to interpret · moderate
• Barbiturates · May decrease serum T4 levels, making the TSH stimulation test hard to interpret · moderate
• Corticosteroids · May decrease serum T4 levels, making the TSH stimulation test hard to interpret · moderate
• Diazepam · May decrease serum T4 levels, making the TSH stimulation test hard to interpret · moderate
• Heparin · May decrease serum T4 levels, making the TSH stimulation test hard to interpret · moderate
• Mitotane · May decrease serum T4 levels, making the TSH stimulation test hard to interpret · moderate
• Phenylbutazone · May decrease serum T4 levels, making the TSH stimulation test hard to interpret · moderate
• Phenytoin · May decrease serum T4 levels, making the TSH stimulation test hard to interpret · moderate
• Salicylates · May decrease serum T4 levels, making the TSH stimulation test hard to interpret · moderate
• Fluorouracil · May cause T4 levels to be increased, making the TSH stimulation test hard to interpret · moderate

모니터링

• Serum total T4 concentrations (baseline and 4-6 hours post-administration)
• Clinical signs of hypersensitivity or anaphylaxis during and immediately after administration
• Serum total T4 levels (baseline and post-stimulation, typically 4-6 hours post-injection)

과용량

Chronic administration at high dosages can produce clinical signs of **hyperthyroidism** (e.g., weight loss, polyphagia, tachycardia, hyperactivity). Massive overdoses can cause clinical signs resembling **thyroid storm** (a life-threatening hypermetabolic state). Treatment is generally supportive and symptomatic; refer to levothyroxine overdose protocols for specific management strategies.