갑상선 자극 호르몬 (티로트로핀)
Thyrotropin (Thyroid Stimulating Hormone)
Thyrotropin alfa (recombinant human TSH)
다른 이름: Thyrogen · Ambinon · Thyreostimulin · Thytropar · Thyroid-stimulating hormone · Thyrotrophic hormone · rhTSH · Recombinant human thyrotropin
VetSheet 수의사 팀 검수업데이트 2026년 4월 5일근거 기반 수의학 참고자료
용량은 수의사 전문가를 위한 임상 참고자료입니다. 반드시 최신 약물 정보 및 개별 환자에 따라 확인하시기 바랍니다.
동물 종별 용량
🌎 NA — North America🌍 EU — Europe
개
| 적응증 | 용량 | 경로 | 빈도 | 기간 | 지역 |
|---|---|---|---|---|---|
| TSH stimulation test | 75 micrograms (total dose) | IV | Once | — | 🌎 NA |
| TSH stimulation test | 50-100 micrograms (0.05-0.1 mg) | IV | Once | — | 🌎 NA |
| TSH stimulation test | 50-150 μg/dog | IV | single dose | 1 day | 🌍 EU |
- TSH stimulation test: Blood samples taken before and 6 hours after rhTSH administration for determination of total serum thyroxine (T4) concentration.
- TSH stimulation test: Measure serum T4 at 0 hours (pre-sample) and 4 hours post. Product may be frozen for at least 8 weeks with no loss of potency.
- TSH stimulation test: Higher doses offer increased discriminatory power in dogs with comorbidities or those receiving thyroid-suppressing drugs.
고양이
| 적응증 | 용량 | 경로 | 빈도 | 기간 | 지역 |
|---|---|---|---|---|---|
| TSH stimulation test | 25 μg/cat | IV | single dose | 1 day | 🌍 EU |
- TSH stimulation test: The diagnostic value in cats has not been fully assessed.
새
| 적응증 | 용량 | 경로 | 빈도 | 기간 | 지역 |
|---|---|---|---|---|---|
| TSH stimulation test | 1 Unit/kg | IM | Once | — | 🌎 NA |
- TSH stimulation test: Draw pre-dose baseline sample. Collect sample for T4 6 hours after dose.
용량은 수의사 전문가를 위한 임상 참고자료입니다. 반드시 최신 약물 정보 및 개별 환자에 따라 확인하시기 바랍니다.
개요
티로트로핀(TSH)은 당단백질 호르몬으로, 수의학에서는 주로 원발성 갑상선 기능 저하증을 진단하기 위한 TSH 자극 검사의 진단제로 사용됩니다. 현재 시판되는 제품은 DNA 재조합 기술을 통해 생산된 인간 유래 제품(rhTSH)입니다.
작용 기전
Thyrotropin binds to TSH receptors on the basolateral membrane of thyroid follicular cells. This binding activates the adenylate cyclase/cAMP pathway, which stimulates multiple steps in thyroid hormone synthesis:
- Increases iodine uptake (trapping) by the thyroid gland.
- Stimulates the iodination of tyrosine residues on thyroglobulin.
- Increases the production and secretion of active thyroid hormones (T3 and T4) into the systemic circulation.
With prolonged use, hyperplasia of thyroid cells may occur, though this is not a concern with single-dose diagnostic use.
안전성·주의사항
금기사항
- Adrenocortical insufficiency (untreated Addison's disease)
- Hyperthyroidism
- Coronary thrombosis
- Hypersensitivity to bovine thyrotropin or human proteins
- Repeated administration is not advisable
- Patients currently receiving levothyroxine therapy
- Use of chemical grade TSH (due to anaphylaxis risk)
부작용
- Hypersensitivity reactions (especially with repeated injections of human-derived proteins in animals)
- Clinical signs of hyperthyroidism (with chronic administration or high doses)
- Anaphylactic responses (specifically associated with chemical grade/bovine TSH; recombinant forms are generally well tolerated)
주의
Hypersensitivity Warning: Because the commercially available product is derived from human sources, hypersensitivity reactions may occur in patients sensitive to human proteins, particularly with repeated use.
- Pregnancy: FDA Category C. Animal studies have shown an adverse effect on the fetus, but there are no adequate studies in humans.
- Nursing: Unknown if excreted in milk, but unlikely to be clinically significant when used for a one-time diagnostic test.
약물 상호작용
May decrease serum T4 levels, making the TSH stimulation test hard to interpret
May decrease serum T4 levels, making the TSH stimulation test hard to interpret
May decrease serum T4 levels, making the TSH stimulation test hard to interpret
May decrease serum T4 levels, making the TSH stimulation test hard to interpret
May decrease serum T4 levels, making the TSH stimulation test hard to interpret
May decrease serum T4 levels, making the TSH stimulation test hard to interpret
May decrease serum T4 levels, making the TSH stimulation test hard to interpret
May decrease serum T4 levels, making the TSH stimulation test hard to interpret
May decrease serum T4 levels, making the TSH stimulation test hard to interpret
May decrease serum T4 levels, making the TSH stimulation test hard to interpret
May cause T4 levels to be increased, making the TSH stimulation test hard to interpret
May cause T4 levels to be increased, making the TSH stimulation test hard to interpret
May cause T4 levels to be increased, making the TSH stimulation test hard to interpret
May cause T4 levels to be increased, making the TSH stimulation test hard to interpret
May cause T4 levels to be increased, making the TSH stimulation test hard to interpret
모니터링
- Serum total T4 concentrations (baseline and 4-6 hours post-administration)
- Clinical signs of hypersensitivity or anaphylaxis during and immediately after administration
- Serum total T4 levels (baseline and post-stimulation, typically 4-6 hours post-injection)
약동학
흡수
Exogenously administered TSH apparently exerts maximal increases in circulating T4 approximately 4-8 hours after IM or IV administration.
대사
Degraded primarily in the kidneys and liver.
배설
Cleared via renal and hepatic pathways.
과다투여
Chronic administration at high dosages can produce clinical signs of hyperthyroidism (e.g., weight loss, polyphagia, tachycardia, hyperactivity).
Massive overdoses can cause clinical signs resembling thyroid storm (a life-threatening hypermetabolic state). Treatment is generally supportive and symptomatic; refer to levothyroxine overdose protocols for specific management strategies.
제품
제형
- Lyophilized powder for injection
- Injectable: 1.1 mg vial (yields 0.9 mg/ml after reconstitution with 1.2 ml sterile water)
인용의약품
- Recombinant (human) Thyrotropin (Thyroid Stimulating Hormone) Powder for Injection, Lyophilized: 1.1 mg per vial; Thyrogen® (Genzyme); (Rx)
- Thyrogen 1.1 mg powder for injection
규제 현황
Human approved drug (Thyrogen) used off-label under the cascade.
Human approved drug (Thyrogen) used off-label under the cascade.
규제 데이터 없음: 🇺🇸 US · 🇭🇰 HK · 🇹🇼 TW · 🇯🇵 JP · 🇰🇷 KR · 🇦🇺 AU
보관·안정성
Unreconstituted thyrotropin alfa should be stored between 2-8°C (36-46°F). Reconstituted solution can be stored up to 24 hours between 2-8°C (36-46°F), avoiding microbial contamination. It is reportedly stable if kept refrigerated (2-8°C) up to 4 weeks and up to 8 weeks if frozen (-20°C). Protect from light. Visually inspect each vial for particulate matter or discoloration before use; do not use if present.
보호자 정보
이 약물은 반려동물의 갑상선 기능을 평가하기 위한 일회성 진단 검사에 사용됩니다. 반려동물은 먼저 채혈을 하고 호르몬 주사를 맞은 뒤, 4~6시간 후에 두 번째 채혈을 하게 됩니다. 알레르기 반응은 매우 드물지만, 안면 부종, 두드러기 또는 호흡 곤란이 관찰되면 즉시 수의사에게 알리십시오.
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