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동물 종별 용량

용량은 면허 수의 전문가를 위한 임상 참고 자료입니다. 항상 최신 라벨과 개별 환자에 대해 확인하십시오.

투여 경로

금기

• Hypersensitivity to tinidazole or other 5-nitroimidazoles (e.g., metronidazole, ronidazole)
• Food-producing animals (prohibited use)

이상반응

• Vomiting
• Inappetence
• Diarrhea
• Neurotoxicity (ataxia, nystagmus, seizures)
• Hypersalivation (due to bitter taste)

약물 상호작용

• Alcohol · May induce a disulfiram-like reaction (nausea, vomiting, cramps).
• Cimetidine · May decrease the metabolism of tinidazole and increase the likelihood of dose-related side effects.
• Ketoconazole · May decrease the metabolism of tinidazole and increase the likelihood of dose-related side effects.
• Cyclosporine · Tinidazole may increase the serum levels of cyclosporine.
• Tacrolimus (systemic) · Tinidazole may increase the serum levels of tacrolimus.
• Fluorouracil (systemic) · Tinidazole may increase the serum levels of fluorouracil and increase the risk of toxicity.
• Lithium · Tinidazole may increase lithium serum levels and increase the risk for lithium toxicity.
• Oxytetracycline · May antagonize the therapeutic effects of metronidazole (and presumably tinidazole).
• Phenobarbital · May increase the metabolism of tinidazole thereby decreasing blood levels.
• Rifampin · May increase the metabolism of tinidazole thereby decreasing blood levels.
• Phenytoin · May increase the metabolism of tinidazole thereby decreasing blood levels.
• Warfarin · May prolong the prothrombin time (PT). Avoid concurrent use if possible; otherwise, intensify monitoring.

모니터링

• Clinical efficacy in treating the infection
• Gastrointestinal tolerance
• Neurological signs (ataxia, nystagmus, seizures)

과용량

Very limited information is available. In rodent studies, the oral LD50 was >3.6 g/kg (mice) and >2 g/kg (rats). Treatment of acute overdoses is **symptomatic and supportive**. * **Decontamination**: Gastric lavage or induction of emesis may be helpful if performed shortly after ingestion and the patient is neurologically appropriate. * **Clearance**: Hemodialysis can remove approximately 43% of the drug in the body (based on human data) in a 6-hour session.