토세라닙

동물 종별 용량

용량은 면허 수의 전문가를 위한 임상 참고 자료입니다. 항상 최신 라벨과 개별 환자에 대해 확인하십시오.

투여 경로

금기

• Breeding, pregnant, or lactating bitches
• Dogs less than 24 months of age or weighing less than 5 kg (safe use not evaluated)
• Pregnant or lactating bitches
• Dogs < 2 years old
• Dogs < 5 kg
• Patients with any signs of gastrointestinal haemorrhage
• Known hypersensitivity to toceranib

이상반응

• Diarrhea (can be severe)
• Decreased or loss of appetite
• Lameness
• Weight loss
• Gastrointestinal bleeding (blood in stool, melena)
• Muscle cramping
• Neutropenia
• Hypoalbuminemia
• Thromboembolic disease (including pulmonary emboli)
• Vasculitis
• Pancreatitis
• Nasal depigmentation
• Change in coat or skin color
• Epistaxis
• Seizures
• Pruritus
• Diarrhoea

약물 상호작용

• NSAIDs (e.g., piroxicam, carprofen) · Increased risk of gastrointestinal ulceration or perforation. Use with extreme caution; never give on the same day as toceranib to avoid exacerbating GI toxicity.
• CYP3A4 Inhibitors (e.g., ketoconazole, fluconazole, itraconazole, clarithromycin, verapamil, grapefruit juice) · May theoretically increase toceranib plasma concentrations and toxicity. Use with caution.
• Corticosteroids · Increased risk of severe gastrointestinal toxicity and ulceration. · major
• NSAIDs · Increased risk of severe gastrointestinal toxicity and ulceration. · major
• Other chemotherapeutic agents · Potential for additive myelosuppression and systemic toxicity. Use with caution. · moderate

모니터링

• CBC (monitor for neutropenia and anemia)
• Hematocrit
• Serum Albumin
• Creatinine
• Serum Phosphate
• Urinalysis
• Full chemistry panels
• Clinical signs of GI toxicity (diarrhea, fresh blood in stool, melena)
• Tumor size and response to therapy
• Blood pressure (baseline and monthly)
• Urinalysis (baseline and monthly, monitor for proteinuria)
• Haematology (baseline and monthly)
• Biochemistry (baseline and monthly, monitor albumin and ALT)
• Coagulation profiles (if adverse signs occur)
• Faecal occult blood tests (if adverse signs occur)
• Weekly owner check-ins for the first 6 weeks to monitor for GI signs

과용량

Toceranib has a **narrow margin of safety**. While specific acute toxicity data is limited, overdoses are likely to cause severe gastrointestinal distress, myelosuppression, and vascular events. > **Action:** In the event of an acute overdose, consider immediate gut decontamination (emesis/activated charcoal) if caught early. Contact an animal poison control center for further guidance and provide aggressive supportive care.