트리엔틴

킬레이트제

트리엔틴은 주로 개의 구리 관련 간병증 치료에 사용되는 경구용 구리 킬레이트제입니다. 페니실라민의 위장관 부작용(예: 심한 구토)을 견디지 못하는 환자에게 중요한 대안 치료제 역할을 합니다.

작용 기전: Trientine acts as a polyamine chelating agent. It binds to systemic copper to form a stable, water-soluble complex (a chelate) that is subsequently eliminated from the body via **urinary excretion**. * **Affinity Profile:** Trientine has a greater affinity for **plasma copper** compared to penicillamine. * Conversely, penicillamine has a higher affinity for **tissue copper**. * By binding circulating copper, trientine creates a concentration gradient that gradually pulls stored copper out of hepatic tissues for elimination.

동물 종별 용량

Dogs

As a chelator for copper hepatotoxicity · 10-15 mg/kg · PO · q12h · 1-2 hours before a meal
As a chelator for copper hepatotoxicity · 10-15 mg/kg · PO · q12h · Give one hour before meals
As a chelator for copper hepatotoxicity · 15-30 mg/kg · PO · q12h · Give prior to meals
Copper hepatotoxicosis · 10-15 mg/kg · PO · q12h · Long-term as needed · Vomiting may be reduced by giving in divided doses with food.

용량은 면허 수의 전문가를 위한 임상 참고 자료입니다. 항상 최신 라벨과 개별 환자에 대해 확인하십시오.

투여 경로

금기

Hypersensitivity to trientine
Cystinuria
Rheumatoid arthritis
Biliary cirrhosis
No specific contraindications available in the monograph, but should be used with caution in patients without confirmed copper storage disease.

이상반응

Acute renal failure (rare but reported in dogs)
Iron deficiency anemia (with long-term use)
Topical contact dermatitis (if powder contacts skin)
Nausea
Vomiting
Abdominal pain
Melaena (dark, tarry stools)
Weakness
Copper deficiency (with chronic therapy)

약물 상호작용

Iron · Iron and trientine mutually inhibit the absorption of one another. Separate doses by at least 2 hours.
Zinc · Trientine may chelate zinc and other essential minerals, reducing their absorption. Separate doses by at least 2 hours.
Iron supplements · Inhibits absorption of iron; separate doses by a minimum of 2 hours · moderate
Zinc supplements · Inhibits absorption of zinc; separate doses by a minimum of 2 hours · moderate
Other mineral supplements · Inhibits absorption of minerals; separate doses by a minimum of 2 hours · moderate

모니터링

Periodic quantitative hepatic copper levels (via liver biopsy)
Renal function parameters (BUN, Creatinine, SDMA, Urinalysis) due to the risk of acute renal failure
Complete Blood Count (CBC) to monitor for iron deficiency anemia
Hepatic copper concentrations (via biopsy)
Liver enzymes (ALT, AST, ALP)
Clinical signs of copper deficiency (e.g., anemia, weakness)
Gastrointestinal tolerance

과용량

Little information is available regarding acute toxicity in veterinary species. In human medicine, a case of a patient ingesting 30 grams of trientine without significant morbidity has been reported. If a massive overdose occurs in a pet, standard gastrointestinal decontamination and supportive care are recommended.

VetSheet 약물 레퍼런스는 면허 수의 전문가를 위한 임상 의사결정 보조 도구이며, 전문적 판단이나 제조사의 최신 라벨을 대신하지 않습니다.