ํด๋ผ์ค๋ก๋ง์ด์
**ํด๋ผ์ค๋ก๋ง์ด์ (Tulathromycin)**์ ํธ๋ฆฌ์๋ฐ๋ผ์ด๋ ํ์ ๊ณ์ด์ ๋ฐํฉ์ฑ, ์ง์์ฑ ๋งํฌ๋ก๋ผ์ด๋๊ณ ํญ์์ ์ ๋๋ค. ์ฃผ๋ก ๋๋๋ฌผ(์ ๋ฐ ๋ผ์ง)์ ํธํก๊ธฐ ์งํ, ์์ ์ง๊ฐ๋ถํจ์ฆ, ์ ์ผ์ฑ ์ ๊ฐ๊ฒฐ๋ง์ผ(ํํฌ์์ด) ์น๋ฃ์ ์ฌ์ฉ๋ฉ๋๋ค. * **๋ ํนํ ๊ตฌ์กฐ**: 3๊ฐ์ ์๋ฏผ๊ธฐ(3์ผ๊ธฐ์ฑ)๋ฅผ ํฌํจํ๊ณ ์์ด ๊ธฐ์กด ๋งํฌ๋ก๋ผ์ด๋๊ณ๋ณด๋ค ๊ทธ๋ ์์ฑ ๋ณ์๊ท ์ ๋ํ ์นจํฌ๋ ฅ์ด ์ฐ์ํฉ๋๋ค. * **ํ์ ์ ๋ฌ**: ์์ฃผ์ ์์ธํฌ(๋์์ธํฌ ๋ฐ ํธ์ค๊ตฌ)์ ๊ด๋ฒ์ํ๊ฒ ์ถ์ ๋์ด ๊ฐ์ผ๋ ํ ์กฐ์ง์ ์ง์ ๊ณ ๋๋์ ์ฝ๋ฌผ์ ์ ๋ฌํฉ๋๋ค. * **ํธ์์ฑ**: ์กฐ์ง ๋ฐ๊ฐ๊ธฐ๊ฐ ๋งค์ฐ ๊ธธ์ด(์์ ํ์์ ์ต๋ 8.75์ผ) ๋จํ ํฌ์ฌ์ฉ์ผ๋ก ๊ฐ๋ฐ๋์์ต๋๋ค. > **์์ ํ**: ์ฃผ๋ก ๊ฐ์ถ์ฉ์ผ๋ก ์น์ธ๋์์ผ๋, ๋ง์์ง์ ๋ก๋์ฝ์ปค์ค ์์ฟ ์ด(*Rhodococcus equi*) ๊ฐ์ผ์ด๋ ์ํ ๋ฐ์ถ๋๋ฌผ์ ๊ฐ์์ฑ ํธํก๊ธฐ ๋ณ์๊ท ์น๋ฃ์ ํ๊ฐ ์ธ(off-label)๋ก ์ฌ์ฉ๋๊ธฐ๋ ํฉ๋๋ค.
์์ฉ ๊ธฐ์ : Tulathromycin binds to the **50S ribosomal subunit** of susceptible bacteria โ blocks transpeptidation and translocation processes โ inhibits RNA-dependent protein synthesis. * Generally considered **bacteriostatic**, but exhibits **bactericidal** activity against key respiratory pathogens like *Mannheimia haemolytica* and *Pasteurella multocida*. * Its low affinity for bacterial efflux pumps allows it to remain and accumulate within the bacteria. * Concentrates in host phagocytic cells (macrophages) โ migrates to sites of inflammation โ releases active drug directly at the infection site, providing targeted therapy.
๋๋ฌผ ์ข ๋ณ ์ฉ๋
- Bovine respiratory disease (BRD), bovine foot rot, infectious bovine keratoconjunctivitis (IBK) ยท 2.5 mg/kg (1.1 mL/100 lb) BW ยท SC ยท single dose ยท Inject subcutaneously in the neck. Do not inject more than 10 mL per injection site.
- Rhodococcus equi infections in foals ยท 2.5 mg/kg ยท IM ยท every 5-7 days ยท Anecdotally used successfully in milder clinical cases.
- Swine respiratory disease (SRD) ยท 2.5 mg/kg (0.25 mL/22 lb) BW ยท IM ยท single dose ยท Inject intramuscularly in the neck. Do not inject more than 2.5 mL per injection site.
์ฉ๋์ ๋ฉดํ ์์ ์ ๋ฌธ๊ฐ๋ฅผ ์ํ ์์ ์ฐธ๊ณ ์๋ฃ์ ๋๋ค. ํญ์ ์ต์ ๋ผ๋ฒจ๊ณผ ๊ฐ๋ณ ํ์์ ๋ํด ํ์ธํ์ญ์์ค.
ํฌ์ฌ ๊ฒฝ๋ก
๊ธ๊ธฐ
- Prior hypersensitivity to tulathromycin or other macrolides
- Female dairy cattle 20 months of age or older
- Calves to be processed for veal
- Pre-ruminating calves (withdrawal period not established)
์ด์๋ฐ์
- Transient hypersalivation
- Transient dyspnea (rare)
- Injection site reactions (swelling, pain, discoloration, trim loss at slaughter)
- Anorexia
- Restlessness and excessive vocalization (swine)
๋ชจ๋ํฐ๋ง
- Clinical efficacy (resolution of respiratory signs, lameness, or ocular lesions)
- Injection site for severe reactions
๊ณผ์ฉ๋
### Cattle Single subcutaneous doses of up to 25 mg/kg caused transient indications of pain at the injection site, including head shaking and pawing at the ground. Injection site swelling, discoloration of subcutaneous tissues, and corresponding histopathologic changes were observed. ### Swine Single IM doses of up to 25 mg/kg caused transient indications of pain at the injection site, restlessness, and excessive vocalization. Brief tremors occurred in one animal receiving 7.5 mg/kg. ### Treatment No systemic treatment for single overdoses should be necessary. Localized treatment at the injection site (e.g., ice pack) to reduce swelling and pain, as well as FDA-approved analgesic medications, can be considered.
VetSheet ์ฝ๋ฌผ ๋ ํผ๋ฐ์ค๋ ๋ฉดํ ์์ ์ ๋ฌธ๊ฐ๋ฅผ ์ํ ์์ ์์ฌ๊ฒฐ์ ๋ณด์กฐ ๋๊ตฌ์ด๋ฉฐ, ์ ๋ฌธ์ ํ๋จ์ด๋ ์ ์กฐ์ฌ์ ์ต์ ๋ผ๋ฒจ์ ๋์ ํ์ง ์์ต๋๋ค.