우르소디올

담즙산 / 간보호제

우르소디올은 천연 친수성 담즙산으로 주로 개와 고양이의 간담도 질환에 대한 보조 치료제로 사용됩니다. 간 보호, 담즙 분비 촉진 및 면역 조절 특성이 있어 독성 담즙산에 의한 간세포 파괴를 줄이고 콜레스테롤 담석 용해를 돕습니다.

작용 기전: Ursodiol exerts its effects through multiple hepatoprotective and choleretic pathways: * **Cholesterol Reduction:** Suppresses hepatic synthesis and secretion of cholesterol and decreases intestinal absorption of cholesterol. * **Gallstone Solubilization:** By reducing cholesterol saturation in the bile, it allows the solubilization of cholesterol-containing gallstones. * **Choleretic Effect:** Increases bile flow, which helps flush toxic bile acids from the liver. * **Cytoprotection:** Reduces the hepatocyte toxic effects of endogenous hydrophobic bile salts (e.g., lithocholate, deoxycholate) by decreasing their detergent action on cell membranes, thereby protecting hepatic cells from apoptosis and necrosis.

동물 종별 용량

Cats

Cholestatic liver disease, cholangitis/cholangiohepatitis, chronic hepatitis, and copper-associated hepatopathy · 10-15 mg/kg PO once daily · PO · q24h · Safe and potentially beneficial.
Chronic active hepatitis, fibrosis, and cirrhosis · 11-15.4 mg/kg PO either once daily or divided twice daily · PO · q12h-q24h · May use as primary or adjunctive therapy. Cats usually get 1/6th of a capsule mixed with a small amount of food. Cats may still eat their food even if drug is sprinkled on top.
Adjunctive treatment of chronic hepatitis · 10 mg/kg/day PO · PO · q24h

Birds

Adjunctive treatment of liver disease · 10-15 mg/kg PO once daily · PO · q24h

Dogs

Adjunctive treatment of chronic hepatitis · 5-15 mg/kg PO divided q12h · PO · q12h · With immunosuppressive therapy. Note: Use of this drug at this dose is preliminary, but promising.
Cholestatic liver disease, cholangitis/cholangiohepatitis, chronic hepatitis, and copper-associated hepatopathy · 10-15 mg/kg PO once daily · PO · q24h · Safe and potentially beneficial.
Chronic active hepatitis, fibrosis and cirrhosis · 11-15.4 mg/kg PO either once daily or divided twice daily · PO · q12h-q24h · May use as primary or adjunctive therapy.

용량은 면허 수의 전문가를 위한 임상 참고 자료입니다. 항상 최신 라벨과 개별 환자에 대해 확인하십시오.

투여 경로

금기

Rabbits and other hindgut fermenters (converted to toxic lithocholic acid)
Biliary obstruction
Biliary fistulas
Cholecystitis
Pancreatitis
Cholangitis (if complete obstruction is present)

이상반응

Diarrhea
Gastrointestinal upset (rare)

약물 상호작용

Aluminum-containing antacids · May bind to ursodiol, thereby reducing its efficacy
Cholestyramine resin · May bind to ursodiol, thereby reducing its efficacy
Taurine · Theoretical concern that chronic administration in cats may lead to taurine deficiency

모니터링

Efficacy via ultrasonography for gallstones
Improved liver function tests for chronic hepatic disease
SGPT/SGOT (AST/ALT) on a routine basis

과용량

Overdosage of ursodiol would most likely cause **diarrhea**. **Treatment:** * Supportive therapy. * Oral administration of an aluminum-containing antacid (e.g., aluminum hydroxide suspension) to bind the drug. * Gastric emptying (if large overdose occurred recently) with concurrent administration of activated charcoal or cholestyramine suspension.

VetSheet 약물 레퍼런스는 면허 수의 전문가를 위한 임상 의사결정 보조 도구이며, 전문적 판단이나 제조사의 최신 라벨을 대신하지 않습니다.