비타민 A / 이소트레티노인

동물 종별 용량

용량은 면허 수의 전문가를 위한 임상 참고 자료입니다. 항상 최신 라벨과 개별 환자에 대해 확인하십시오.

투여 경로

금기

• Pregnant animals
• Breeding animals
• Patients at high risk for thrombosis
• Neonates

이상반응

• Teratogenicity (fetal malformations)
• Keratoconjunctivitis sicca (KCS / dry eye)
• Hepatotoxicity
• Hyperlipidaemia
• Hypercalcaemia (due to bone calcium loss with prolonged use)
• Skin redness and pigmentation
• Haematological abnormalities
• Nervous system changes
• Bone changes
• Thrombosis
• Anaphylactoid reactions

약물 상호작용

• Ciclosporin · Oral vitamin A may alter ciclosporin levels; requires close monitoring. · moderate
• Other topical drugs · Do not use topical vitamin A preparations simultaneously with other topical drugs. · moderate
• Vitamin A · May enhance vitamin A absorption, utilization, and storage. · minor

모니터링

• Signs of vitamin A toxicity
• Tear production (Schirmer Tear Test) for KCS
• Liver enzymes (ALT, AST, ALP)
• Serum calcium levels
• Serum triglycerides/lipids
• Ciclosporin levels (if used concurrently)
• Ciclosporin blood levels (if used concurrently)
• Coagulation parameters (in patients at risk for thrombosis)
• Liver enzymes (if treating hepatopathy)

과용량

High doses or prolonged use can lead to severe **vitamin A toxicity**. Signs of toxicity include: - **Hepatotoxicity** - **Hyperlipidaemia** - **Hypercalcaemia** (due to promotion of calcium loss from bone) - Severe skin, haematological, and nervous system abnormalities. > **Treatment:** Discontinue the drug immediately and provide supportive care. Monitor liver enzymes and serum calcium.