๋นํ๋ฏผ E / ์ ๋ ๋
๋นํ๋ฏผ E์ ์ ๋ ๋์ ์๋์ง ํจ๊ณผ๋ฅผ ๋ด๋ ํญ์ฐํ ํน์ฑ ๋๋ฌธ์ ์์ฃผ ํจ๊ป ์ฌ์ฉ๋์ง๋ง, ๋นํ๋ฏผ E๋ ๋จ๋ ๋ณด์ถฉ์ ๋ก๋ ๋๋ฆฌ ์ฌ์ฉ๋ฉ๋๋ค. - **๋นํ๋ฏผ E(์ํ-ํ ์ฝํ๋กค)**๋ ์ฐํ์ ์์์ผ๋ก๋ถํฐ ์ธํฌ๋ง์ ๋ณดํธํ๋ ๋ฐ ํ์์ ์ธ ์ง์ฉ์ฑ ๋นํ๋ฏผ์ ๋๋ค. ์๋ฐ์ฑ ํ๋ฐ์ฑ ๋ฃจํธ์ค, ๋ชจ๋ญ์ถฉ์ฆ๊ณผ ๊ฐ์ ํผ๋ถ ์งํ, ๊ฐ ์งํ ๋ฐ ์ ๊ฒฝ๊ณ ์งํ์ ๋ณด์กฐ ์๋ฒ์ผ๋ก ์ฌ์ฉ๋ฉ๋๋ค. - **์ ๋ ๋**์ ํญ์ฐํ ํจ์์ ์ค์ํ ๋ณด์กฐ ์ธ์๋ก ์์ฉํ๋ ๋ฏธ๋ ๋ฏธ๋ค๋์ ๋๋ค. ๋ณตํฉ์ ๋ ์ฃผ๋ก ๊ฐ์ถ์ ๋ฐฑ๊ทผ๋ณ๊ณผ ๊ฐ์ **์ ๋ ๋-ํ ์ฝํ๋กค ๊ฒฐํ์ฆ(STD)**์ ์น๋ฃ ๋๋ ์๋ฐฉ์ ์ฌ์ฉ๋ฉ๋๋ค. > **์์ ํ:** ๋นํ๋ฏผ E๋ ์์ ๋ฒ์๊ฐ ๋์ง๋ง, **์ ๋ ๋์ ๊ณผ๋ค ๋ณต์ฉ ์ ๋งค์ฐ ๋ ์ฑ์ด ๊ฐํฉ๋๋ค**. ๋ณตํฉ์ ๋ ์ ๋ ๋ ๋๋์ ๋ฐ๋ผ ์ธ์ฌํ๊ฒ ์ฉ๋์ ์กฐ์ ํด์ผ ํ๋ฉฐ, FDA ์น์ธ์ ๋ฐ์ ๋๋ฌผ์ข ์๊ฒ๋ง ์ฌ์ฉํด์ผ ํฉ๋๋ค.
์์ฉ ๊ธฐ์ : Both Vitamin E and Selenium are intricately involved in the cellular metabolism of sulfur and the prevention of oxidative stress. - **Vitamin E** acts as a potent biological free radical scavenger. It prevents the oxidation of polyunsaturated fatty acids within cellular and subcellular membranes. - **Selenium** is an essential structural component of the enzyme **glutathione peroxidase** โ this enzyme catalyzes the reduction of lipid hydroperoxides to their corresponding alcohols, neutralizing their potential to cause cellular damage. Together, they protect against red blood cell hemolysis and prevent the destructive action of peroxidase on unsaturated bonds in cell membranes.
๋๋ฌผ ์ข ๋ณ ์ฉ๋
- Vitamin E/Selenium deficiency (using Bo-Se) ยท Lambs (2 weeks of age or older): 1 mL per 40 lbs. body weight IM or SC (1 mL minimum). Ewes: 2.5 mL/100 lbs. body weight IM or SC. ยท IM/SC ยท Single dose ยท Slaughter withdrawal = 14 days.
- Vitamin E/Selenium deficiency (using L-Se) ยท Lambs: 1 mL SC or IM in newborns and 4 mL SC or IM in lambs 2 weeks of age or older ยท SC/IM ยท Single dose ยท Slaughter withdrawal = 14 days.
- Treatment of tocopherol deficiency associated with exocrine pancreatic disease ยท 30 Units PO once daily for one month then every 1-2 weeks as needed ยท PO ยท q24h ยท 1 month, then q1-2 weeks
- Adjunctive treatment of hepatic lipidosis ยท 10 Units/kg once PO once daily ยท PO ยท q24h
- Vitamin E/Selenium deficiency (using Mu-Se) ยท For weanling calves: 1 mL per 200 lbs. body weight IM or SC. For breeding beef cows: 1 mL per 200 lbs. body weight during middle third of pregnancy and 30 days before calving IM or SC. ยท IM/SC ยท Variable ยท Slaughter withdrawal = 30 days.
- Vitamin E/Selenium deficiency (using Bo-Se) ยท Calves: 2.5-3.75 mL/100 lbs body weight (depending on severity of condition and geographical area) IM or SC. ยท IM/SC ยท Single dose ยท Slaughter withdrawal = 30 days.
- Adjunctive treatment of ionophore (monensin) toxicity ยท 4-12 Units/kg PO once daily ยท PO ยท q24h
ํฌ์ฌ ๊ฒฝ๋ก
๊ธ๊ธฐ
- Use of combination products in non-FDA approved species
- Use of Bo-Se in newborn pigs
์ด์๋ฐ์
- Anaphylactoid reactions
- Transient muscle soreness at injection sites (IM)
- Selenium toxicity (depression, ataxia, dyspnea, blindness, diarrhea, muscle weakness, garlic breath)
์ฝ๋ฌผ ์ํธ์์ฉ
- Iron ยท Large doses of vitamin E may delay the hematologic response to iron therapy in patients with iron deficiency anemia.
- Mineral oil ยท May reduce the absorption of orally administered vitamin E.
- Vitamin A ยท Absorption, utilization, and storage may be enhanced by vitamin E.
- Warfarin ยท Vitamin E may increase the effects of warfarin.
๋ชจ๋ํฐ๋ง
- Clinical efficacy
- Blood selenium levels (when using combination products)
- Glutathione peroxidase activity (optional)
๊ณผ์ฉ๋
Selenium is quite toxic in overdose quantities, but has a fairly wide safety margin. Cattle have tolerated chronic doses of 0.6 mg/kg/day with no adverse effects (approximate therapeutic dose is 0.06 mg/kg). **Clinical signs of selenium toxicity include:** - Depression, ataxia, dyspnea, blindness, diarrhea, muscle weakness - A distinct **'garlic' odor** on the breath - **Horses:** May become blind, paralyzed, slough their hooves, and lose hair from the tail and mane. - **Dogs:** May exhibit anorexia, vomiting, and diarrhea at high dosages. Large overdoses of **vitamin E** alone can cause coagulopathies.
VetSheet ์ฝ๋ฌผ ๋ ํผ๋ฐ์ค๋ ๋ฉดํ ์์ ์ ๋ฌธ๊ฐ๋ฅผ ์ํ ์์ ์์ฌ๊ฒฐ์ ๋ณด์กฐ ๋๊ตฌ์ด๋ฉฐ, ์ ๋ฌธ์ ํ๋จ์ด๋ ์ ์กฐ์ฌ์ ์ต์ ๋ผ๋ฒจ์ ๋์ ํ์ง ์์ต๋๋ค.