비타민 E / 셀레늄
Vitamin E / Selenium
Alpha-tocopherol / Sodium selenite
다른 이름: Emulsivit E-300 · Vital E-300 · Equ-SeE · Equ-Se5E · Mu-Se · Bo-Se · L-Se · E-Se · Seletoc · Aquasol E · Nutr-E-Sol · Alpha-tocopherol · Sodium selenite
VetSheet 수의사 팀 검수업데이트 2026년 4월 5일근거 기반 수의학 참고자료
용량은 수의사 전문가를 위한 임상 참고자료입니다. 반드시 최신 약물 정보 및 개별 환자에 따라 확인하시기 바랍니다.
동물 종별 용량
🌎 NA — North America🌍 EU — Europe
개
| 적응증 | 용량 | 경로 | 빈도 | 기간 | 지역 |
|---|---|---|---|---|---|
| Adjunctive treatment of discoid lupus erythematosus, canine demodicosis or acanthosis nigricans | 200-400 Units PO three times daily | PO | q8h | — | 🌎 NA |
| Adjunctive treatment of cholestatic hepatopathies; necroinflammatory hepatopathies | 10-15 Units/kg per day PO as alpha-tocopherol acetate | PO | q24h | — | 🌎 NA |
| Adjunctive treatment of copper-associated hepatopathy | 400-600 Units PO per day | PO | q24h | — | 🌎 NA |
| Treatment of tocopherol deficiency associated with exocrine pancreatic disease | 100-400 Units PO once daily for one month then every 1-2 weeks as needed | PO | q24h | 1 month, then q1-2 weeks | 🌎 NA |
| Vitamin E/Selenium deficiency (using Seletoc) | Initially, 1 mL per 20 pounds of body weight (minimum 0.25 mL; maximum 5 mL) SC, or IM in divided doses in 2 or more sites. Repeat dose at 3 day intervals until satisfactory results then switch to maintenance dose. Maintenance dose: 1 mL per 40 lbs body weight (minimum 0.25 mL) repeat at 3-7 day intervals (or longer) to maintain. | SC/IM | q3d initially, then q3-7d | — | 🌎 NA |
- Adjunctive treatment of discoid lupus erythematosus, canine demodicosis or acanthosis nigricans: Variable efficacy, but relatively innocuous at these dosages
- Vitamin E/Selenium deficiency (using Seletoc): If no response in 14 days reevaluate.
고양이
| 적응증 | 용량 | 경로 | 빈도 | 기간 | 지역 |
|---|---|---|---|---|---|
| Treatment of tocopherol deficiency associated with exocrine pancreatic disease | 30 Units PO once daily for one month then every 1-2 weeks as needed | PO | q24h | 1 month, then q1-2 weeks | 🌎 NA |
| Adjunctive treatment of hepatic lipidosis | 10 Units/kg once PO once daily | PO | q24h | — | 🌎 NA |
말
| 적응증 | 용량 | 경로 | 빈도 | 기간 | 지역 |
|---|---|---|---|---|---|
| Adjunctive treatment of ionophore (monensin) toxicity | 4-12 Units/kg PO once daily | PO | q24h | — | 🌎 NA |
| Adjunctive therapy for EPM | 8000-9000 Units PO per day | PO | q24h | — | 🌎 NA |
| Adjunctive therapy for metabolic syndrome | 10,000 Units PO once daily | PO | q24h | — | 🌎 NA |
| Adjunctive treatment of perinatal asphyxia syndrome (hypoxic ischemic encephalopathy) | Foals: 4,000 Units PO once daily; Mares: 10,000 Units PO once daily | PO | q24h | — | 🌎 NA |
| Vitamin E/Selenium deficiency (using E-Se) | 1 mL/100 lbs. body weight slow IV or deep IM (in 2 or more sites; gluteal or cervical muscles). May be repeated at 5-10 day intervals. | IV/IM | q5-10d | — | 🌎 NA |
- Vitamin E/Selenium deficiency (using E-Se): Give slowly when administering IV.
소
| 적응증 | 용량 | 경로 | 빈도 | 기간 | 지역 |
|---|---|---|---|---|---|
| Vitamin E/Selenium deficiency (using Mu-Se) | For weanling calves: 1 mL per 200 lbs. body weight IM or SC. For breeding beef cows: 1 mL per 200 lbs. body weight during middle third of pregnancy and 30 days before calving IM or SC. | IM/SC | Variable | — | 🌎 NA |
| Vitamin E/Selenium deficiency (using Bo-Se) | Calves: 2.5-3.75 mL/100 lbs body weight (depending on severity of condition and geographical area) IM or SC. | IM/SC | Single dose | — | 🌎 NA |
- Vitamin E/Selenium deficiency (using Mu-Se): Slaughter withdrawal = 30 days.
- Vitamin E/Selenium deficiency (using Bo-Se): Slaughter withdrawal = 30 days.
돼지
| 적응증 | 용량 | 경로 | 빈도 | 기간 | 지역 |
|---|---|---|---|---|---|
| Vitamin E/Selenium deficiency (using Bo-Se) | Sows and weanling pigs: 1mL/40 lbs. body weight IM or SC (1 mL minimum). | IM/SC | Single dose | — | 🌎 NA |
| Vitamin E/Selenium deficiency (using L-Se) | Baby Pigs: 1 mL SC or IM. | SC/IM | Single dose | — | 🌎 NA |
- Vitamin E/Selenium deficiency (using Bo-Se): Do not use on newborn pigs. Slaughter withdrawal = 14 days.
- Vitamin E/Selenium deficiency (using L-Se): Slaughter withdrawal = 14 days.
양
| 적응증 | 용량 | 경로 | 빈도 | 기간 | 지역 |
|---|---|---|---|---|---|
| Vitamin E/Selenium deficiency (using Bo-Se) | Lambs (2 weeks of age or older): 1 mL per 40 lbs. body weight IM or SC (1 mL minimum). Ewes: 2.5 mL/100 lbs. body weight IM or SC. | IM/SC | Single dose | — | 🌎 NA |
| Vitamin E/Selenium deficiency (using L-Se) | Lambs: 1 mL SC or IM in newborns and 4 mL SC or IM in lambs 2 weeks of age or older | SC/IM | Single dose | — | 🌎 NA |
- Vitamin E/Selenium deficiency (using Bo-Se): Slaughter withdrawal = 14 days.
- Vitamin E/Selenium deficiency (using L-Se): Slaughter withdrawal = 14 days.
용량은 수의사 전문가를 위한 임상 참고자료입니다. 반드시 최신 약물 정보 및 개별 환자에 따라 확인하시기 바랍니다.
개요
비타민 E와 셀레늄은 시너지 효과를 내는 항산화 특성 때문에 자주 함께 사용되지만, 비타민 E는 단독 보충제로도 널리 사용됩니다.
- 비타민 E(알파-토코페롤)는 산화적 손상으로부터 세포막을 보호하는 데 필수적인 지용성 비타민입니다. 원반성 홍반성 루푸스, 모낭충증과 같은 피부 질환, 간 질환 및 신경계 질환의 보조 요법으로 사용됩니다.
- 셀레늄은 항산화 효소의 중요한 보조 인자로 작용하는 미량 미네랄입니다. 복합제는 주로 가축의 백근병과 같은 셀레늄-토코페롤 결핍증(STD)의 치료 또는 예방에 사용됩니다.
임상 팁: 비타민 E는 안전 범위가 넓지만, 셀레늄은 과다 복용 시 매우 독성이 강합니다. 복합제는 셀레늄 농도에 따라 세심하게 용량을 조절해야 하며, FDA 승인을 받은 동물종에게만 사용해야 합니다.
작용 기전
Both Vitamin E and Selenium are intricately involved in the cellular metabolism of sulfur and the prevention of oxidative stress.
- Vitamin E acts as a potent biological free radical scavenger. It prevents the oxidation of polyunsaturated fatty acids within cellular and subcellular membranes.
- Selenium is an essential structural component of the enzyme glutathione peroxidase → this enzyme catalyzes the reduction of lipid hydroperoxides to their corresponding alcohols, neutralizing their potential to cause cellular damage.
Together, they protect against red blood cell hemolysis and prevent the destructive action of peroxidase on unsaturated bonds in cell membranes.
안전성·주의사항
금기사항
- Use of combination products in non-FDA approved species
- Use of Bo-Se in newborn pigs
부작용
- Anaphylactoid reactions
- Transient muscle soreness at injection sites (IM)
- Selenium toxicity (depression, ataxia, dyspnea, blindness, diarrhea, muscle weakness, garlic breath)
주의
Vitamin E/selenium products should only be used in the species for which they are FDA-approved. Because selenium can be extremely toxic, the promiscuous use of these products cannot be condoned. Give slowly when administering intravenously to horses.
약물 상호작용
Large doses of vitamin E may delay the hematologic response to iron therapy in patients with iron deficiency anemia.
May reduce the absorption of orally administered vitamin E.
Absorption, utilization, and storage may be enhanced by vitamin E.
Vitamin E may increase the effects of warfarin.
모니터링
- Clinical efficacy
- Blood selenium levels (when using combination products)
- Glutathione peroxidase activity (optional)
약동학
흡수
After absorption, vitamin E is transported in the circulatory system via beta-lipoproteins. Absorption of vitamin E may be impaired in patients with severe cholestatic liver disease or in animals with fat malabsorption syndromes.
분포
Vitamin E is distributed to all tissues and stored in adipose tissue. It is only marginally transported across the placenta.
대사
Vitamin E is metabolized in the liver.
배설
Vitamin E is excreted primarily into the bile.
과다투여
Selenium is quite toxic in overdose quantities, but has a fairly wide safety margin. Cattle have tolerated chronic doses of 0.6 mg/kg/day with no adverse effects (approximate therapeutic dose is 0.06 mg/kg).
Clinical signs of selenium toxicity include:
- Depression, ataxia, dyspnea, blindness, diarrhea, muscle weakness
- A distinct 'garlic' odor on the breath
- Horses: May become blind, paralyzed, slough their hooves, and lose hair from the tail and mane.
- Dogs: May exhibit anorexia, vomiting, and diarrhea at high dosages.
Large overdoses of vitamin E alone can cause coagulopathies.
제품
제형
- Injection
- Oral powder
- Oral liquid
- Tablets
- Capsules
동물용의약품
- Vitamin E Injection: 300 mg/mL (Emulsivit E-300, Vital E-300)
- Vitamin E/Selenium Oral: Equ-SeE, Equ-Se5E
- Vitamin E/Selenium Injection: Mu-Se (5 mg Se/mL), Bo-Se (1 mg Se/mL), L-Se (0.25 mg Se/mL), E-Se (2.5 mg Se/mL), Seletoc (1 mg Se/mL)
인용의약품
- Vitamin E Tablets: 100 Units, 200 Units, 400 Units, 500 Units & 800 Units
- Vitamin E Capsules: 100 Units, 200 Units, 400 Units & 1000 Units
- Vitamin E Drops: 15 Units/0.3 mL
- Vitamin E Liquid: 15 Units/30 mL, 798 Units/30 mL
규제 현황
규제 데이터 없음: 🇺🇸 US · 🇪🇺 EU · 🇬🇧 UK · 🇭🇰 HK · 🇹🇼 TW · 🇯🇵 JP · 🇰🇷 KR · 🇦🇺 AU
보관·안정성
Vitamin E/Selenium for injection should be stored at temperatures less than 25°C (77°F).
보호자 정보
- 엄격한 용량 준수: 처방된 용량을 절대 초과하지 마십시오. 비타민 E는 비교적 안전하지만, 셀레늄을 과다 보충하면 매우 독성이 강할 수 있습니다.
- 중독 징후: 반려동물의 입에서 '마늘' 냄새가 나거나, 극심한 쇠약, 비틀거림, 구토 또는 호흡 곤란이 관찰되면 즉시 수의사에게 연락하십시오.
- 투여 방법: 경구용 액제나 캡슐을 투여할 경우, 급여와 관련된 수의사의 지시를 따르십시오(지용성 비타민의 흡수를 높이기 위해 보통 음식과 함께 투여합니다).
- 보관: 우발적인 섭취를 방지하기 위해 모든 보충제는 어린이와 동물의 손이 닿지 않는 곳에 보관하십시오.
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