비타민 E / 셀레늄

영양 보충제 / 지용성 비타민

비타민 E와 셀레늄은 시너지 효과를 내는 항산화 특성 때문에 자주 함께 사용되지만, 비타민 E는 단독 보충제로도 널리 사용됩니다. - **비타민 E(알파-토코페롤)**는 산화적 손상으로부터 세포막을 보호하는 데 필수적인 지용성 비타민입니다. 원반성 홍반성 루푸스, 모낭충증과 같은 피부 질환, 간 질환 및 신경계 질환의 보조 요법으로 사용됩니다. - **셀레늄**은 항산화 효소의 중요한 보조 인자로 작용하는 미량 미네랄입니다. 복합제는 주로 가축의 백근병과 같은 **셀레늄-토코페롤 결핍증(STD)**의 치료 또는 예방에 사용됩니다. > **임상 팁:** 비타민 E는 안전 범위가 넓지만, **셀레늄은 과다 복용 시 매우 독성이 강합니다**. 복합제는 셀레늄 농도에 따라 세심하게 용량을 조절해야 하며, FDA 승인을 받은 동물종에게만 사용해야 합니다.

작용 기전: Both Vitamin E and Selenium are intricately involved in the cellular metabolism of sulfur and the prevention of oxidative stress. - **Vitamin E** acts as a potent biological free radical scavenger. It prevents the oxidation of polyunsaturated fatty acids within cellular and subcellular membranes. - **Selenium** is an essential structural component of the enzyme **glutathione peroxidase** → this enzyme catalyzes the reduction of lipid hydroperoxides to their corresponding alcohols, neutralizing their potential to cause cellular damage. Together, they protect against red blood cell hemolysis and prevent the destructive action of peroxidase on unsaturated bonds in cell membranes.

동물 종별 용량

Sheep

Vitamin E/Selenium deficiency (using Bo-Se) · Lambs (2 weeks of age or older): 1 mL per 40 lbs. body weight IM or SC (1 mL minimum). Ewes: 2.5 mL/100 lbs. body weight IM or SC. · IM/SC · Single dose · Slaughter withdrawal = 14 days.
Vitamin E/Selenium deficiency (using L-Se) · Lambs: 1 mL SC or IM in newborns and 4 mL SC or IM in lambs 2 weeks of age or older · SC/IM · Single dose · Slaughter withdrawal = 14 days.

Cats

Treatment of tocopherol deficiency associated with exocrine pancreatic disease · 30 Units PO once daily for one month then every 1-2 weeks as needed · PO · q24h · 1 month, then q1-2 weeks
Adjunctive treatment of hepatic lipidosis · 10 Units/kg once PO once daily · PO · q24h

Cattle

Vitamin E/Selenium deficiency (using Mu-Se) · For weanling calves: 1 mL per 200 lbs. body weight IM or SC. For breeding beef cows: 1 mL per 200 lbs. body weight during middle third of pregnancy and 30 days before calving IM or SC. · IM/SC · Variable · Slaughter withdrawal = 30 days.
Vitamin E/Selenium deficiency (using Bo-Se) · Calves: 2.5-3.75 mL/100 lbs body weight (depending on severity of condition and geographical area) IM or SC. · IM/SC · Single dose · Slaughter withdrawal = 30 days.

Horses

Adjunctive treatment of ionophore (monensin) toxicity · 4-12 Units/kg PO once daily · PO · q24h

투여 경로

POIMIVSCtopical

금기

Use of combination products in non-FDA approved species
Use of Bo-Se in newborn pigs

이상반응

Anaphylactoid reactions
Transient muscle soreness at injection sites (IM)
Selenium toxicity (depression, ataxia, dyspnea, blindness, diarrhea, muscle weakness, garlic breath)

약물 상호작용

Iron · Large doses of vitamin E may delay the hematologic response to iron therapy in patients with iron deficiency anemia.
Mineral oil · May reduce the absorption of orally administered vitamin E.
Vitamin A · Absorption, utilization, and storage may be enhanced by vitamin E.
Warfarin · Vitamin E may increase the effects of warfarin.

모니터링

Clinical efficacy
Blood selenium levels (when using combination products)
Glutathione peroxidase activity (optional)

과용량

Selenium is quite toxic in overdose quantities, but has a fairly wide safety margin. Cattle have tolerated chronic doses of 0.6 mg/kg/day with no adverse effects (approximate therapeutic dose is 0.06 mg/kg). **Clinical signs of selenium toxicity include:** - Depression, ataxia, dyspnea, blindness, diarrhea, muscle weakness - A distinct **'garlic' odor** on the breath - **Horses:** May become blind, paralyzed, slough their hooves, and lose hair from the tail and mane. - **Dogs:** May exhibit anorexia, vomiting, and diarrhea at high dosages. Large overdoses of **vitamin E** alone can cause coagulopathies.

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