์กธ๋ผ์ ํ ๋ฐ ํธ๋ ํ๋ฏผ
**์กธ๋ผ์ ํ/ํธ๋ ํ๋ฏผ**(์ผ๋ฐ์ ์ผ๋ก ์กฐ๋ ํธ(Zoletil) ๋๋ ํ ๋ผ์กธ(Telazol)๋ก ์๋ ค์ง)์ ๊ฐ์ ๊ณ ์์ด์ ์ ์ ๋ง์ทจ๋ฅผ ์ํด ์์ํ์์ ๋๋ฆฌ ์ฌ์ฉ๋๋ ๋ณตํฉ ์ฃผ์ฌ์ฉ ๋ง์ทจ์ ์ ๋๋ค. ํด๋ฆฌ์ฑ ๋ง์ทจ์ (ํธ๋ ํ๋ฏผ)์ ๋ฒค์กฐ๋์์ ํ(์กธ๋ผ์ ํ)์ ๊ฒฐํฉํ์ฌ ๊ทผ์ก ์ด์์ ๋๋ฐํ ๋ง์ทจ๋ฅผ ์ ๊ณตํฉ๋๋ค. > **์์ ๊ฒฝ๊ณ :** ์ด ๋ณตํฉ์ ๋ ํต์ฆ์ด ์๋ ์์ ์ ๋จ๋ ๋ง์ทจ์ ๋ก ์ฌ์ฉํด์๋ **์ ๋ฉ๋๋ค**. ์ถฉ๋ถํ ๋ด์ฅ ์งํต ํจ๊ณผ๊ฐ ๋ถ์กฑํ๋ฏ๋ก ์ ์ ํ ์งํต์ (์: ๋ง์ฝ์ฑ ์งํต์ , NSAIDs)์ ๋ณ์ฉํด์ผ ํฉ๋๋ค. **์์ ํ:** ์ด ์ฝ๋ฌผ ์กฐํฉ์ผ๋ก๋ถํฐ์ ํ๋ณต์ ์ง์ฐ๋ ์ ์์ผ๋ฉฐ(2-6์๊ฐ), ํนํ ๊ณ ์ฉ๋์ ํฌ์ฌ๋ฐ์ ๊ฐ์์๋ ํ๋ณต ๊ณผ์ ์ด ๊ฑฐ์น ๊ฑฐ๋ ํฅ๋ถ ์ํ๋ฅผ ๋ณด์ผ ์ ์์ต๋๋ค. ์ ๋ง์ทจ์ (์: ์ํ-2 ์์ฉ์ ๋๋ ํ๋ ธํฐ์์ง๊ณ ์ฝ๋ฌผ, ๋จ ์ํธ์์ฉ ์ฃผ์)๋ฅผ ํฌ์ฌํ๋ฉด ํ๋ณต์ด ๋ ๋ถ๋๋ฌ์์ง๋ ๊ฒฝ์ฐ๊ฐ ๋ง์ต๋๋ค. ๊ณ ์์ด์ ํ๋ณต ์๊ฐ์ ์ผ๋ฐ์ ์ผ๋ก ๊ฐ๋ณด๋ค ๋ ๊น๋๋ค.
์์ฉ ๊ธฐ์ : The drug is a 1:1 combination of two active principles with complementary mechanisms: * **Zolazepam:** A benzodiazepine that enhances the activity of **GABA** (gamma-aminobutyric acid) โ the major inhibitory neurotransmitter within the CNS. This provides sedative, anxiolytic, and muscle-relaxing actions, counteracting the muscle rigidity typically caused by dissociative agents. * **Tiletamine:** A dissociative anesthetic (pharmacologically similar to ketamine) that antagonizes **NMDA (glutamic acid) receptors** โ depresses certain cerebral regions (thalamus and cortex) while the limbic system remains active, generating a state of dissociative anesthesia.
๋๋ฌผ ์ข ๋ณ ์ฉ๋
- General anaesthesia ยท 5-10 mg/kg ยท IV ยท single dose ยท Duration of anaesthesia is 20-60 minutes ยท Dose refers to the combined tiletamine/zolazepam (100 mg/ml). Adjust depending on degree of pain expected and depth required.
- General anaesthesia ยท 7-25 mg/kg ยท IM ยท single dose ยท Duration of anaesthesia is 20-60 minutes ยท Dose refers to the combined tiletamine/zolazepam (100 mg/ml). Adjust depending on degree of pain expected and depth required.
- General anaesthesia ยท 5-7.5 mg/kg ยท IV ยท single dose ยท Duration of anaesthesia is 20-60 minutes ยท Dose refers to the combined tiletamine/zolazepam (100 mg/ml). Adjust depending on degree of pain expected and depth required.
- General anaesthesia ยท 10-15 mg/kg ยท IM ยท single dose ยท Duration of anaesthesia is 20-60 minutes ยท Dose refers to the combined tiletamine/zolazepam (100 mg/ml). Adjust depending on degree of pain expected and depth required.
์ฉ๋์ ๋ฉดํ ์์ ์ ๋ฌธ๊ฐ๋ฅผ ์ํ ์์ ์ฐธ๊ณ ์๋ฃ์ ๋๋ค. ํญ์ ์ต์ ๋ผ๋ฒจ๊ณผ ๊ฐ๋ณ ํ์์ ๋ํด ํ์ธํ์ญ์์ค.
ํฌ์ฌ ๊ฒฝ๋ก
๊ธ๊ธฐ
- Severe cardiac disease
- Severe respiratory disease
- Hypertensive disease
- Renal insufficiency
- Pancreatic insufficiency
- Hepatic insufficiency
- Head trauma or intracranial tumours
- Pregnancy (crosses the placenta and causes fatal respiratory depression in neonates)
์ด์๋ฐ์
- Excessive salivation (ptyalism)
- Muscle rigidity during recovery
- Prolonged and excitable recovery (especially in dogs at higher doses)
- Pain on intramuscular injection (particularly in cats)
- Respiratory depression (can be fatal in neonates)
- Hypothermia
์ฝ๋ฌผ ์ํธ์์ฉ
- Phenothiazines (e.g., Acepromazine) ยท Increased cardiorespiratory depression and increased hypothermic effect during the last phase of anesthesia. ยท major
- Chloramphenicol ยท Slows down the elimination of the anesthetics if used during the pre- or intraoperative period. ยท moderate
๋ชจ๋ํฐ๋ง
- Heart rate and rhythm
- Respiratory rate and depth
- Body temperature (monitor closely for hypothermia)
- Depth of anesthesia (jaw tone, palpebral reflex)
- Quality of recovery (monitor for excitation or rigidity)
๊ณผ์ฉ๋
Overdosage increases the risk of severe **cardiorespiratory depression**, prolonged anesthesia, and highly excitable or rough recoveries. Treatment is supportive, including mechanical ventilation if respiratory failure occurs, thermal support for hypothermia, and potentially benzodiazepine antagonists (flumazenil) for the zolazepam component, though this leaves the tiletamine unopposed.
VetSheet ์ฝ๋ฌผ ๋ ํผ๋ฐ์ค๋ ๋ฉดํ ์์ ์ ๋ฌธ๊ฐ๋ฅผ ์ํ ์์ ์์ฌ๊ฒฐ์ ๋ณด์กฐ ๋๊ตฌ์ด๋ฉฐ, ์ ๋ฌธ์ ํ๋จ์ด๋ ์ ์กฐ์ฌ์ ์ต์ ๋ผ๋ฒจ์ ๋์ ํ์ง ์์ต๋๋ค.