Aurothioglucose

Aurothioglucose is an injectable **gold salt** historically used in veterinary medicine for its immunomodulatory and anti-inflammatory properties. * This therapy, known as **chrysotherapy**, was primarily utilized for treating severe immune-mediated skin diseases such as **pemphigus foliaceus** and immune-mediated polyarthritis. * **Clinical Pearl:** Due to the advent of safer, faster-acting, and more effective immunosuppressive agents (e.g., cyclosporine, mycophenolate, glucocorticoids), the use of aurothioglucose has largely fallen out of favor in modern veterinary practice. * It requires a prolonged onset of action (often weeks to months) and carries a significant risk of severe, potentially life-threatening adverse effects, including profound bone marrow suppression and nephrotoxicity.

กลไกการออกฤทธิ์: The exact mechanism of **chrysotherapy** remains incompletely understood, but it is known to exert profound immunomodulatory effects. * **Macrophage Inhibition:** Gold compounds are taken up by **macrophages** → inhibition of phagocytosis → decreased release of lysosomal enzymes and inflammatory mediators. * **T-Cell Modulation:** Alters cellular immunity by reducing the proliferation and activation of **T-lymphocytes**. * **Autoantibody Reduction:** Decreases the production of **rheumatoid factor** and other autoantibodies. * Inhibits **prostaglandin synthesis** and complement activation, contributing to its anti-inflammatory effects.

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