Butaphosphan with Cyanocobalamin

**Butaphosphan with Cyanocobalamin** is a combination nutritional supplement primarily used in large animal and production medicine. It provides a parenteral source of organic phosphorus and Vitamin B12. * **Butaphosphan**: An organic phosphorus compound that supports energy metabolism and assimilation of nutrients. * **Cyanocobalamin**: A synthetic form of Vitamin B12 essential for cellular metabolism, DNA synthesis, and red blood cell production. > **Clinical Pearl**: In dairy cattle, this combination is frequently utilized to manage metabolic demands during the periparturient period. Studies show it can increase post-partum glucose availability, decrease peripheral fat mobilization, and significantly lower the rate of hyperketonemia (subclinical ketosis) in mature cows.

กลไกการออกฤทธิ์: * **Butaphosphan** → Acts as a readily available source of phosphorus, a critical structural component of **ATP (adenosine triphosphate)**, nucleic acids, and cell membranes. It supports gluconeogenesis and overall energy utilization. * **Cyanocobalamin (Vitamin B12)** → Acts as a vital coenzyme for **methylmalonyl-CoA mutase** (crucial for the metabolism of propionate into glucose in ruminants) and **methionine synthase**. * **Synergistic Effect** → Together, they enhance energy metabolism, improve post-partum glucose availability, and decrease ketone body formation by optimizing the TCA cycle and reducing peripheral fat mobilization.

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