Calcitonin Salmon

Calcitonin salmon is a synthetic polypeptide hormone primarily used in veterinary medicine to manage severe **hypercalcemia** (e.g., secondary to cholecalciferol rodenticide toxicity, apocrine gland anal sac adenocarcinoma, or lymphoma) and nutritional secondary hyperparathyroidism (NSHP) in reptiles. It may also be used as an adjunctive treatment for severe bone pain. * **Clinical Pearl**: Salmon calcitonin is utilized therapeutically because it is approximately 50 times more potent and has a longer duration of action than mammalian (human) calcitonin. * **Limitation**: Its clinical utility is often limited by expense and the rapid development of **tachyphylaxis** (downregulation of receptors), meaning it typically loses efficacy after a few days of continuous treatment. * **Caution**: Do not confuse calcitonin (which lowers serum calcium) with calcitriol (which raises serum calcium).

กลไกการออกฤทธิ์: Calcitonin exerts a multitude of physiologic effects to rapidly lower serum calcium levels: * **Bone**: Binds directly to **calcitonin receptors** on osteoclasts → profoundly inhibits osteoclastic bone resorption → decreases the release of calcium and phosphorus from bone into the extracellular fluid. * **Kidneys**: Acts on the renal tubules → reduces tubular reabsorption of calcium, phosphate, sodium, magnesium, potassium, and chloride → promotes their renal excretion. * **Gastrointestinal Tract**: Increases jejunal secretion of water, sodium, potassium, and chloride (but notably not calcium).

ข้อมูลอ้างอิงยาของ VetSheet มีไว้สำหรับสัตวแพทย์ผู้มีใบอนุญาตเพื่อช่วยในการตัดสินใจทางคลินิก ไม่ใช่สิ่งทดแทนการวินิจฉัยของผู้เชี่ยวชาญหรือฉลากล่าสุดของผู้ผลิต