Chromium Picolinate

Chromium picolinate is a trace metal **nutraceutical** that may be used as an adjunctive treatment for diabetes mellitus and obesity, particularly in cats. * **Clinical Efficacy**: Its efficacy remains controversial in veterinary medicine, and it does not appear to be useful in dogs with diabetes mellitus. * **Biologic Forms**: Trivalent chromium (Cr III) is the biologically active form found in supplements and food, which is distinct from the highly toxic and carcinogenic hexavalent chromium (Cr VI) used in industrial applications. * **Safety**: Generally considered safe at recommended dosages, though its true clinical benefit requires individual patient trials.

กลไกการออกฤทธิ์: Chromium is an active component of the **glucose tolerance factor (GTF)**, a complex of molecules including glycine, glutamic acid, cysteine, and nicotinic acid. While its exact role in carbohydrate and nitrogen metabolism is not fully elucidated, it is thought to enhance **insulin receptor** sensitivity and facilitate glucose transport into cells. * **GTF → Insulin Receptor Binding → Enhanced Intracellular Glucose Uptake** * It does *not* lower blood glucose levels in normal, healthy patients.

ข้อมูลอ้างอิงยาของ VetSheet มีไว้สำหรับสัตวแพทย์ผู้มีใบอนุญาตเพื่อช่วยในการตัดสินใจทางคลินิก ไม่ใช่สิ่งทดแทนการวินิจฉัยของผู้เชี่ยวชาญหรือฉลากล่าสุดของผู้ผลิต