Sodium cromoglicate

Sodium cromoglicate (also known as cromolyn sodium) is a **mast cell stabilizer** used primarily for the management of **allergic conjunctivitis** and **allergic rhinitis**. Its action is localized to the site of application, making it effective for topical use in the eyes and respiratory tract. > **Clinical Pearl:** It is most effective when used prophylactically before exposure to known allergens, as it prevents degranulation rather than reversing the effects of already released histamine.

กลไกการออกฤทธิ์: Sodium cromoglicate works by **stabilizing mast cell membranes**. It inhibits the release of inflammatory mediators (such as **histamine** and **leukotrienes**) from sensitized mast cells by preventing calcium influx across the cell membrane. Allergen exposure → Mast cell activation blocked → **Prevention of degranulation** → Decreased allergic inflammation.

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