Decoquinate

Decoquinate is a **4-hydroxy quinolone** antiprotozoal agent primarily used as a **coccidiostat** in livestock and poultry. While highly effective for *preventing* coccidiosis by arresting the parasite's life cycle at the sporozoite stage, it is **ineffective against adult coccidia** and cannot treat active clinical infections. In small animal medicine, its most notable off-label use is in dogs for the long-term prevention of **hepatozoonosis relapse** (caused by *Hepatozoon americanum*) following initial acute therapy. Because it is a static agent (coccidiostatic rather than coccidiocidal), it relies on the host's immune system to clear the inhibited parasites.

กลไกการออกฤทธิ์: Decoquinate acts specifically on the **sporozoite stage** of the coccidian life cycle. * Sporozoites can still penetrate host intestinal cells, but further intracellular development is halted. * **Mechanism**: It disrupts electron transport within the **mitochondrial cytochrome system** of the parasite → inhibits respiration and ATP energy production → prevents maturation and replication.

ข้อมูลอ้างอิงยาของ VetSheet มีไว้สำหรับสัตวแพทย์ผู้มีใบอนุญาตเพื่อช่วยในการตัดสินใจทางคลินิก ไม่ใช่สิ่งทดแทนการวินิจฉัยของผู้เชี่ยวชาญหรือฉลากล่าสุดของผู้ผลิต