Dexpanthenol

Dexpanthenol (also known as d-Panthenol) is an alcohol derivative of **pantothenic acid (Vitamin B5)**. * **Primary Uses:** Nutritional supplementation (often included in parenteral vitamin complexes) and topical wound healing. * **Historical Use:** Used as a mild gastrointestinal prokinetic to stimulate peristalsis (e.g., for paralytic ileus, post-operative atony, or equine colic), though its clinical efficacy for this indication is highly debated in modern veterinary medicine. > **Clinical Pearl:** While largely replaced by more effective and targeted prokinetics (such as metoclopramide, cisapride, or lidocaine CRIs) for gastrointestinal stasis, dexpanthenol remains a common ingredient in intravenous fluid vitamin additives and topical dermatological preparations due to its excellent safety profile and role in cellular metabolism.

กลไกการออกฤทธิ์: Dexpanthenol acts as a precursor and is rapidly converted to **pantothenic acid** in vivo. * Pantothenic acid is a fundamental component of **Coenzyme A (CoA)**. * CoA facilitates critical acetylation reactions → essential for the synthesis of the neurotransmitter **acetylcholine (ACh)**. * Increased ACh availability → enhances parasympathetic tone → stimulates gastrointestinal smooth muscle contraction and peristalsis. * In topical applications, it promotes epithelialization and granulation tissue formation.

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