Dinoprost

Dinoprost tromethamine is a synthetic analogue of **Prostaglandin F2 alpha (PGF2α)**. In veterinary medicine, it is primarily used for its ecbolic effects to stimulate **uterine contractions** and induce **cervical relaxation**, making it a key medical treatment for **open pyometra**. > **WARNING:** Pregnant women and asthmatics should strictly avoid handling this medication due to the risk of inducing bronchospasm or miscarriage. **Clinical Pearl:** While the primary indication listed for small animals is open pyometra, PGF2α is also widely used for luteolysis (corpus luteum regression) in large animals and occasionally for pregnancy termination in small animals.

กลไกการออกฤทธิ์: Dinoprost acts directly on the myometrium and corpus luteum. * Binds to specific **FP receptors** on smooth muscle cells. * → Increases intracellular calcium concentrations. * → Induces strong, rhythmic **uterine contractions**. * → Concurrently causes **cervical relaxation** to allow expulsion of uterine contents. * → Induces luteolysis (regression of the corpus luteum), leading to a rapid drop in progesterone levels.

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