Kaolin/Pectin

Kaolin/pectin is an oral gastrointestinal combination product historically used as an anti-diarrheal and adsorbent agent. * **Kaolin** is a naturally occurring hydrated aluminum silicate that is powdered and refined. It is practically insoluble in water. * **Pectin** is a carbohydrate polymer consisting primarily of partially methoxylated polygalacturonic acids, obtained from citrus rinds or apple pomace. **Clinical Pearls & Expert Notes:** > **Efficacy Warning:** The clinical efficacy of kaolin/pectin is highly questionable. While it may improve stool consistency (making it less fluid), studies show it does not decrease stool frequency, water content, or overall weight. It is largely considered obsolete in modern veterinary practice for severe diarrhea. > **Toxicity Alert:** Many human over-the-counter products that formerly contained kaolin/pectin (such as **Kaopectate®**) have been reformulated. In the US, Kaopectate® now contains **bismuth subsalicylate**, which is a salicylate (aspirin-like) compound that can be highly toxic to cats. Always verify the active ingredients of OTC anti-diarrheal liquids before administration.

กลไกการออกฤทธิ์: Kaolin/pectin acts locally within the gastrointestinal tract through physical binding and coating mechanisms: * **Adsorption:** Kaolin physically binds (adsorbs) to bacteria, enterotoxins, and potentially other noxious substances in the gut lumen, preventing their systemic absorption or local mucosal damage. * **Mucosal Protection:** The viscous suspension coats the inflamed gastrointestinal mucosa, providing a physical barrier against irritation. * **pH Alteration:** The pectin component is broken down into **galacturonic acid** in the intestinal lumen → decreases the local pH, which may create a less favorable environment for certain pathogenic bacteria.

ข้อมูลอ้างอิงยาของ VetSheet มีไว้สำหรับสัตวแพทย์ผู้มีใบอนุญาตเพื่อช่วยในการตัดสินใจทางคลินิก ไม่ใช่สิ่งทดแทนการวินิจฉัยของผู้เชี่ยวชาญหรือฉลากล่าสุดของผู้ผลิต