Lamivudine

**Lamivudine** (also known as **3TC**) is an antiviral medication primarily used in veterinary medicine for the management of **Feline Immunodeficiency Virus (FIV)**. In asymptomatic cats, it may delay the onset of the clinical phase. In symptomatic cats, it is often used as part of a combination therapy to improve recovery. > **Clinical Warning:** Lamivudine can cause bone marrow suppression; regular hematological monitoring is essential. **Clinical Pearl:** Combining lamivudine with zidovudine (AZT) has been shown to be more effective at reducing viral load and improving CD4/CD8 ratios over a 1-year period than zidovudine monotherapy.

กลไกการออกฤทธิ์: Lamivudine is a **nucleoside reverse transcriptase inhibitor (NRTI)**. It acts as an analogue of cytidine. Once phosphorylated to its active triphosphate form intracellularly, it competes with natural substrates and incorporates into viral DNA. This causes **chain termination** → inhibits the **viral reverse transcriptase** enzyme → prevents viral replication.

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