Octreotide

Octreotide is a **somatostatin analogue** used primarily for the management of pancreatic endocrine tumours (e.g., **insulinoma**, **gastrinoma**) and **acromegaly** in veterinary medicine. > **Clinical Warning:** Research suggests that octreotide is not useful in most insulinomas. Tumours not expressing somatostatin receptors will not respond to therapy. **Clinical Pearl:** While octreotide has been used for acromegaly, newer somatostatin analogues such as pasireotide hold more promise for treatment, though they are currently expensive.

กลไกการออกฤทธิ์: Octreotide acts as a synthetic **somatostatin analogue**. It binds to **somatostatin receptors** (SSTRs) → inhibits the release of several hormones, including growth hormone (GH), insulin, glucagon, and gastrin, as well as reducing splanchnic blood flow and gastrointestinal motility.

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