Sarolaner
Sarolaner is an isoxazoline-class ectoparasiticide used for the treatment and prevention of flea, tick, and mite infestations in dogs and cats. It is available as a standalone oral tablet for dogs (Simparica) and in combination with selamectin as a topical spot-on for cats (Stronghold Plus). > **Important:** Parasites need to start feeding on the host to become exposed to sarolaner; therefore, the transmission of infectious parasite-borne diseases cannot be completely excluded. **Clinical Pearl:** Isoxazolines have revolutionized the treatment of demodicosis and sarcoptic mange due to their high efficacy and ease of use. However, as a class effect, they should be used with caution in animals with a known history of seizures or neurologic disorders.
กลไกการออกฤทธิ์: Sarolaner acts at **ligand-gated chloride channels**, specifically those gated by the neurotransmitter **gamma-aminobutyric acid (GABA)** and glutamate. Binding to these receptors → blocks pre- and post-synaptic transfer of chloride ions across cell membranes → causes uncontrolled neuromuscular activity → leads to the death of the parasite. It has highly selective toxicity for arthropods compared to mammals.
ขนาดยาตามชนิดสัตว์
- Treatment of fleas, ticks, ear mites (Otodectes cynotis), demodicosis (Demodex canis), and Sarcoptes scabiei · 2-4 mg/kg · PO · monthly · Monthly (duration depends on parasite targeted) · Administer every month.
- Treatment of fleas, ticks, ear mites, biting lice, adult roundworms, adult hookworms, and prevention of heartworm disease · 1 mg/kg sarolaner (with 6 mg/kg selamectin) · topical · monthly · Monthly · Administer monthly using the combination spot-on product.
ขนาดยาเป็นข้อมูลอ้างอิงทางคลินิกสำหรับสัตวแพทย์ผู้มีใบอนุญาต โปรดตรวจสอบกับฉลากล่าสุดและผู้ป่วยแต่ละรายเสมอ
วิธีการให้ยา
ข้อห้ามใช้
- Dogs < 8 weeks of age
- Dogs < 1.3 kg body weight
- Cats < 8 weeks of age
- Cats < 1.25 kg body weight
- Known hypersensitivity to the active substance
อาการไม่พึงประสงค์
- Mild gastrointestinal signs (vomiting, diarrhea)
- Mild pruritus or alopecia at the site of application (spot-on product)
- Neurologic signs (tremors, ataxia, seizures) - rare class effect of isoxazolines
อันตรกิริยาระหว่างยา
- NSAIDs · Sarolaner is highly bound to plasma proteins and might compete with other highly bound drugs, potentially increasing free fractions. · moderate
- Warfarin · Potential competition for plasma protein binding sites. · moderate
- Milbemycin oxime · No interactions observed when co-administered. · null
- Moxidectin · No interactions observed when co-administered. · null
- Pyrantel pamoate · No interactions observed when co-administered. · null
การติดตาม
- Efficacy of parasite control
- Monitor for gastrointestinal upset after administration
- Monitor for neurological signs in susceptible individuals
การได้รับยาเกินขนาด
Overdose may increase the risk of adverse effects, particularly gastrointestinal signs (vomiting, diarrhea) and potentially neurological signs (tremors, ataxia, seizures). Treatment is symptomatic and supportive as there is no specific antidote.
ข้อมูลอ้างอิงยาของ VetSheet มีไว้สำหรับสัตวแพทย์ผู้มีใบอนุญาตเพื่อช่วยในการตัดสินใจทางคลินิก ไม่ใช่สิ่งทดแทนการวินิจฉัยของผู้เชี่ยวชาญหรือฉลากล่าสุดของผู้ผลิต